Caracterização do complexo de inclusão ropivacaína: beta-ciclodextrina

Characteriza of the inclusion complex ropivacaine: beta-cyclodextrin. Ropivacaine (RVC) is a widely used local anesthetic. The complexation of RVC with beta-cyclodextrin (beta-CD) is of great interest for the development of more efficient local anesthetic formulations. The present work focuses on the characterization of the RVC:beta-CD complex by nuclear magnetic resonance (NMR). The stoichiometry of the complex is 1:2 RVC:beta-CD. DOSY-NMR shows that the association constant is 55.5 M-1. Longitudinal relaxation time results show that RVC changes its mobility in the presence of beta-CD. This study is focused on the physicochemical characterization of inclusion complexes that are potentials options for pain treatment.

Bibliographic Details

Main Authors:	Fraceto,Leonardo Fernandes, Gonçalves,Marcos Moisés, Moraes,Carolina Morales, Araújo,Daniele Ribeiro de, Zanella,Luciana, Paula,Eneida de, Pertinhez,Thelma de Aguiar
Format:	Digital revista
Language:	Portuguese
Published:	Sociedade Brasileira de Química 2007
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000500028
Tags:	Add Tag No Tags, Be the first to tag this record!