High vancomycin resistance among biofilms produced by Staphylococcus species isolated from central venous catheters

Biofilm production is an important mechanism that allows microbes to escape host defences and antimicrobial therapy. Vancomycin has been used largely for the treatment of methicillin-resistant staphylococcal infections. Here, we determined the minimal inhibitory concentration (MIC) and minimal biofilm eradication concentration (MBEC) for 82 Staphylococcus species isolated from central venous catheters (CVC). Our results showed that the 41 strong and moderate-biofilm-producing isolates presented a higher MBEC/MIC ratio for vancomycin than the 24 weak-biofilm-producing isolates, illustrating the importance of biofilm production ability and the difficulty in treating biofilm-related infections. The MBEC was significantly higher in moderate-biofilm-producing isolates than in weak-biofilm-producing isolates (p < 0.001) and in strong-biofilm-producing isolates than in weak-biofilm-producing isolates (p = 0.001). The correlation between the MIC and the MBEC was poor. Based on our results, we recommend that bacterial biofilms be suspected in all cases of CVC infection.

Detalles Bibliográficos

Autores principales:	Antunes,Ana Lúcia Souza, Bonfanti,Jéssica Weis, Perez,Leandro Reus Rodrigues, Pinto,Camille Cattani Ferreira, Freitas,Ana Lúcia Peixoto de, Macedo,Alexandre José, Barth,Afonso Luis
Formato:	Digital revista
Idioma:	English
Publicado:	Instituto Oswaldo Cruz, Ministério da Saúde 2011
Acceso en línea:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000100008
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