Cytokine profile associated with chronic and acute human schistosomiasis mansoni

The production and regulation of interleukin (IL) IL-13, IL-4 and interferon-gamma (IFN-³) was evaluated in 43 schistosomiasis patients with different clinical forms. Whole-blood cultures cytokine production in response to soluble egg antigen (SEA), soluble worm adult preparation (SWAP), mitogens, neutralizing antibodies or recombinant IL-13 were measured by ELISA. After SWAP stimulation, chronic patients, particularly hepatointestinals, produced higher levels of IL-4 in comparison with acute patients, suggesting the presence of a type 2 cytokine profile in these patients. Following SEA and SWAP stimulation, hepatosplenic (HS) patients showed increased levels of IFN-³ when compared with acute patients, indicating that HS disease in humans is associated with a type 1 cytokine response. The mechanisms of immune regulation are apparently different between the clinical stages of the disease, some of which are antigen-specific.

Bibliographic Details

Main Authors:	Morais,Clarice Neuenschwander Lins de, Souza,Joelma Rodrigues de, Melo,Wlademir Gomes, Aroucha,Marcílio L, Miranda,Paulo, Domingues,Ana Lúcia Coutinho, Abath,Frederico Guilherme Coutinho, Montenegro,Silvia Maria Lucena
Format:	Digital revista
Language:	English
Published:	Instituto Oswaldo Cruz, Ministério da Saúde 2008
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000600009
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