In vitro antiviral activity of antimicrobial peptides against herpes simplex virus 1, adenovirus, and rotavirus

Peptides with broad-spectrum antimicrobial activity, known as antimicrobial peptides, have been isolated from distinct organisms. This paper describes the in vitro evaluation of the cytotoxicity and antiviral activity of nine peptides with different structures and origins against herpes simplex virus type 1, human adenovirus respiratory strain, and rotavirus SA11. Most of the evaluated peptides presented antiviral activity but they were only active near cytotoxic concentrations. Nevertheless, these results seem promising, and further modifications on the peptide's structures may improve their selectivity and reduce their cytotoxicity.

Bibliographic Details

Main Authors:	Carriel-Gomes,Márcia Cristina, Kratz,Jadel Müller, Barracco,Margherita Anna, Bachére,Evelyne, Barardi,Célia Regina Monte, Simões,Cláudia Maria Oliveira
Format:	Digital revista
Language:	English
Published:	Instituto Oswaldo Cruz, Ministério da Saúde 2007
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000400007
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