Prognostic Factors in Severe Chagasic Heart Failure

Abstract Background: Prognostic factors are extensively studied in heart failure; however, their role in severe Chagasic heart failure have not been established. Objectives: To identify the association of clinical and laboratory factors with the prognosis of severe Chagasic heart failure, as well as the association of these factors with mortality and survival in a 7.5-year follow-up. Methods: 60 patients with severe Chagasic heart failure were evaluated regarding the following variables: age, blood pressure, ejection fraction, serum sodium, creatinine, 6-minute walk test, non-sustained ventricular tachycardia, QRS width, indexed left atrial volume, and functional class. Results: 53 (88.3%) patients died during follow-up, and 7 (11.7%) remained alive. Cumulative overall survival probability was approximately 11%. Non-sustained ventricular tachycardia (HR = 2.11; 95% CI: 1.04 - 4.31; p<0.05) and indexed left atrial volume ≥ 72 mL/m2 (HR = 3.51; 95% CI: 1.63 - 7.52; p<0.05) were the only variables that remained as independent predictors of mortality. Conclusions: The presence of non-sustained ventricular tachycardia on Holter and indexed left atrial volume > 72 mL/m2 are independent predictors of mortality in severe Chagasic heart failure, with cumulative survival probability of only 11% in 7.5 years.

Bibliographic Details

Main Authors:	Costa,Sandra de Araújo, Rassi,Salvador, Freitas,Elis Marra da Madeira, Gutierrez,Natália da Silva, Boaventura,Fabiana Miranda, Sampaio,Larissa Pereira da Costa, Silva,João Bastista Masson
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Cardiologia - SBC 2017
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2017000300246
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