Prevalence of antinuclear autoantibodies in the serum of normal blood dornors

OBJECTIVE:To examine the presence of serum antinuclear autoantibodies in a healthy population. METHODS: Serum of 500 normal blood donors between 18 and 60 years of age were tested for the presence of autoantibodies. Antinuclear antibodies were detected by indirect immunofluorescence technique using HEp-2 epithelial cells as the substrate. The presence of dnaN was detected by indirect immunofluorescence technique using Critidia lucillae as the substrate. Anti-SSA (RO), anti-SSB (LA), anti-Sm, and anti-RNP were determined by double radial immunodiffusion. RESULTS: In the evaluation of the presence of serum antibodies, antinuclear antibodies were detected in 22.6% of the sera. The presence of other antibodies was not significant. The majority of the titers were 1:40. CONCLUSION: The presence of autoantibodies is not necessarily pathologic and has to be related to the age group, gender, and clinical condition of the patient.

Detalles Bibliográficos

Autores principales:	Fernandez,Solange Assuncion Villagra, Lobo,Alice Zoghbi Coelho, Oliveira,Zilda Najjar Prado de, Fukumori,Ligia Maria Ichimura, Périgo,Alexandre Marques, Rivitti,Evandro A.
Formato:	Digital revista
Idioma:	English
Publicado:	Faculdade de Medicina / Universidade de São Paulo - FM/USP 2003
Acceso en línea:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812003000600005
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