"In vitro" activity of gentian violet against asexual Plasmodium falciparum parasites

"In vitro" activity of gentian violet against asexual Plasmodium falciparum parasites

In order to investigate whether gentian violet exhibited "in vitro" inhibitory activity against Plasmodium falciparum, the Authors have carried out 20 sensitivity tests according to the microtechnique described by RIECK MANN et al.5. Results have shown inhibition of schizonts'maturation at the following concentration: 1/1000; 1/1500; 1/2000; 1/2500; 1/3000 and 1/4000, thus demonstrating inhibitory activity of the tested dye against asexual blood parasites. The present data suggest gentain violet may be possibly used in the prophylaxis of transfusion-acquired malaria.

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Bibliographic Details
Main Authors: Yang,Shen Lin, Di Santi,Silvia Maria, Amato Neto,Vicente, Moreira,Antonio Augusto Baillot, Pinto,Pedro Luiz Silva, Boulos,Marcos, Campos,Rubens, Sant'Ana,Eunice José de, Shiroma,Mario
Format: Digital revista
Language:English
Published: Instituto de Medicina Tropical de São Paulo 1988
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651988000100003
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