Association of high-risk human papillomavirus with ocular surface squamous neoplasia: a case-control study in Mexico.

Abstract: Objective: To investigate the association of high-risk human papilloma virus (HR-HPV) and other risk factors with ocular surface squamous cell neoplasia (OSSN). Materials and methods: We obtained DNA from 22 fresh frozen OSSN tissues and 22 pterygia as controls, we used a broad-spectrum HPV DNA amplification short PCR fragment to identify HPV infection in all specimens and then genotyped HPV by a reverse hybridization line probe assay. We also obtained demographic, sun exposure, and tobacco consumption information. Results: HR-HPV frequency was 40.9% in the OSSN group and 4.5% in the pterygia group (p=0.009). After covariate adjustment, OSSN was associated with HR-HPV (OR=16.3, 95%CI=1.2,218.1, p=0.03) and sunburn (OR=10.8, 95%CI=1.8,86.0, p=0.02). Conclusions: Ocular surface squamous cell neoplasia is a multifactorial disease. The strong association between HR-HPV and OSSN, suggests that HR-HPV could play an etiological role in OSSN development.

Bibliographic Details

Main Authors:	Parra-Colin,Paola De La, Pichardo-Bahena,Raúl, Méndez-Martínez,Rocío, García-Carrancá,Alejandro, Santamaría-Olmedo,Mónica, Barrientos-Gutiérrez,Tonatiuh, Lazcano-Ponce,Eduardo, Hidalgo-Bravo,Alberto
Format:	Digital revista
Language:	English
Published:	Instituto Nacional de Salud Pública 2022
Online Access:	http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0036-36342022000200209
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