Importance of genetic polymorphisms in the response to age-related macular degeneration treatment

Age-related macular degeneration (AMD) is a degenerative disorder that affects the central retina and involves the Bruch's membrane, the retinal pigment epithelium and the photoreceptors. Recent studies have shown that polymorphisms of the CFH, LOC387715 and VEGF genes are associated with AMD. Herein, we review the literature to analyze the association between the main genetic polymorphisms and the response to the existing therapeutic modalities. Patients with CFH high-risk alleles show a poorer response to preventive treatment of AMD with antioxidants and zinc.The association between genetic polymorphisms and response to photodynamic therapy and antiangiogenic drugs, however, is controversial until now.

Bibliographic Details

Main Authors:	Veloso,Carlos Eduardo dos Reis, Almeida,Luciana Negrão Frota de, De Marco,Luiz Armando, Vianna,Raul Nunes Galvarro, Nehemy,Márcio Bittar
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Oftalmologia 2012
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802012000300011
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