Quantification of cerebrospinal fluid ferritin as a biomarker for CNS malignant infiltration

Several markers have been studied for their ability to make the CNS infiltration diagnosis earlier and more precise; previous studies showed that CSF ferritin concentrations were higher in patients with malignant invasion of CNS. The objective was to determine the importance of CSF ferritin as a biomarker for the diagnosis of CNS neoplasic infiltration. This study is based on 93 CSF samples, divided into five groups: malignant cells present (n13); malignant cells not present (n26); inflammatory neurological diseases (n16); neurocysticercosis (n20); acute bacterial meningitis (n18). CSF ferritin values were determined by micro particle enzyme immunoassay. CSF ferritin level (mean±SD) in the group with neoplasic cells in the CSF was 42.8±49.7 ng /mL, higher than in the other groups (p<0.0001). We conclude that CSF ferritin with the cut off 20 ng/mL could be an adjuvant biomarker to the diagnosis of CNS malignant infiltration.

Bibliographic Details

Main Authors:	Almeida,Sérgio Monteiro de, Cunha,Dione Sosnitzki da, Yamada,Edna, Doi,Elvira Missako, Ono,Margaret
Format:	Digital revista
Language:	English
Published:	Academia Brasileira de Neurologia - ABNEURO 2008
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000500022
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