Late-onset persistent retinal microvascular changes after bone marrow transplantation: 3-year follow-up

Purpose: To describe a case of persistent retinopathy after bone marrow transplantation in the absence of radiation therapy. Methods: Case Report. Results: A 42 year-old man developed bilateral visual loss 15 months after receiving a bone marrow transplant for acute leukemia. The patient was treated with a high dose of cyclosporin A and oral corticosteroids. No radiation therapy was given. Late-onset, multiple, bilateral cotton-wool spots developed 15 months after the bone marrow transplantation and still persist. After three years other cotton-wool spots arose in the absence of any immunosuppressive therapy. Conclusions: Bone marrow transplantation microvasculopathy of the retina may be related to certain combinations of chemotherapy drugs or immunosuppression itself and may persist in the absence of these immunosuppressive drugs.

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Auteurs principaux: Muccioli,Cristina, Belfort Jr,Rubens, Jorge,Rodrigo, Farah,Michel Eid, Pereira,Mauricio B.
Format: Digital revista
Langue:English
Publié: Conselho Brasileiro de Oftalmologia 2002
Accès en ligne:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492002000300017
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