Strategies Towards the Synthesis of N2-Substituted 1,2,3-Triazoles
Abstract The chemistry of 1,2,3-triazoles gained much attention since the discovery of the copper catalyzed Alkyne-azide cycloaddition (CuAAC) reaction which delivers exclusively the 1,4-regioisomer in high yields. On the other hand there is still no universal methodology capable of delivering the N2 substituted regioisomer. The unique properties of these N2-substituted 1,2,3-triazoles have stimulated synthetic efforts on the developments of methodologies capable of delivering it in high yield and selectivity. These efforts are the subject of the presented review.
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| Main Authors: | , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
Academia Brasileira de Ciências
2019
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| Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000200401 |
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