Molluscicidal activity of 2-hydroxy-[1,4]naphthoquinone and derivatives

Molluscicidal activity of 2-hydroxy-[1,4]naphthoquinone and derivatives

The toxic profile of lawsone (2-hydroxy-[1,4]naphthoquinone) and a series of [1,4]naphthoquinone derivatives was evaluated against the brine shrimp Artemia salina and against the mollusk Biomphalaria glabrata, the main transmitting vector of schistosomiasis in Brazil. Of the seventeen compounds tested nine fell below the threshold of 100 µg/mL set for potential molluscicidal activity by the World Health Organization. As a general rule derivatives with non-polar substituents presented the highest molluscicidal activities. These substances showed significant toxicity in A. salina lethality bioassay.

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Bibliographic Details
Main Authors: Camara,Celso A., Silva,Tania M.S., da-Silva,Thiago G., Martins,Rodrigo M., Barbosa,Ticiano P., Pinto,Angelo C., Vargas,Maria D.
Format: Digital revista
Language:English
Published: Academia Brasileira de Ciências 2008
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000200011
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000200011

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