Dendritic spines and IGF-1
Growth factors, such as insulin-like growth factor 1 (IGF-1), among others are known for their critical involvement in learning and memory processes. IGF-1 regulates cognitive functions, synapse density, neurotransmission, and adult neurogenesis and induces structural and synaptic plasticity-specific changes. Although IGF-1 has been suggested to participate in different memory processes, its role in memories associated with negative emotional experiences still remains to be elucidated. The principal aim of the present study was to test whether IGF-1 overexpression using adenoviral vectors in basolateral amygdala (BLA) influences both the expression and formation of contextual fear memory, as well as the hippocampal structural plasticity associated with such memory trace.We found that IGF-1 overexpression promotes the formation and expression of a specific contextual fear memory trace, and such effect persisted at least 7 days after recall. Moreover, the overexpression of this growth factor in BLA upregulates the activation of the ERK/MAPK pathway in this brain structure. In addition, intra-BLA IGF-1 overexpression causes dorsal hippocampus (DH) structural plasticity modifications promoting changes in the proportion of mature dendritic spines in the CA1 region, after a weak conditioning protocol. The present findings contribute to the knowledge underlying BLA-DH trace memory of fear and reveal important new insights into the neurobiology and neurochemistry of fear acquisition modulated by IGF-1 overexpression. The understanding of how IGF-1 modulates the formation of a fear contextual trace may pave the way for the development of novel therapeutic strategies focused on fear, anxiety, and trauma-related disorders.
| Autores principales: | , , , , , , |
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| Otros Autores: | |
| Formato: | Fil: Fil: Champarini, Leandro Gabriel. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina. biblioteca |
| Idioma: | eng |
| Publicado: |
2023
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| Materias: | Neurociencias, Medicina Básica, Ciencias médicas y de la salud, https://purl.org/becyt/ford/3, Basolateral amygdala, Dendritic spines, Dorsal hippocampus, Fear memory, |
| Acceso en línea: | http://hdl.handle.net/11086/548611 |
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