Chemistry of Hydrogen Peroxide Formation and Elimination in Mammalian Cells, and Its Role in Various Pathologies
Hydrogen peroxide (H2O2) is a compound involved in some mammalian reactions and processes. It modulates and signals the redox metabolism of cells by acting as a messenger together with hydrogen sulfide (H2S) and the nitric oxide radical (•NO), activating specific oxidations that determine the metabolic response. The reaction triggered determines cell survival or apoptosis, depending on which downstream metabolic pathways are activated. There are several ways to produce H2O2 in cells, and cellular systems tightly control its concentration. At the cellular level, the accumulation of hydrogen peroxide can trigger inflammation and even apoptosis, and when its concentration in the blood reaches toxic levels, it can lead to bioenergetic failure. This review summarizes existing research from a chemical perspective on the role of H2O2 in various enzymatic pathways and how this biochemistry leads to physiological or pathological responses.
| Principais autores: | , , , , |
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| Outros Autores: | |
| Formato: | artículo biblioteca |
| Idioma: | English |
| Publicado em: |
Multidisciplinary Digital Publishing Institute
2022-07-25
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| Assuntos: | Hydrogen peroxide H2O2, metabolic response, induced pathologies, |
| Acesso em linha: | http://hdl.handle.net/10261/279191 http://dx.doi.org/10.13039/501100007757 http://dx.doi.org/10.13039/501100014180 http://dx.doi.org/10.13039/501100003329 |
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