PrPC governs susceptibility to prion strains in bank vole, while other host factors modulate strain features

Bank vole is a rodent species that shows differential susceptibility to the experimental transmission of different prion strains. In this work, the transmission features of a panel of diverse prions with distinct origins were assayed both in bank vole expressing methionine at codon 109 (Bv109M) and in transgenic mice expressing physiological levels of bank vole PrPC (the BvPrP-Tg407 mouse line). This work is the first systematic comparison of the transmission features of a collection of prion isolates, representing a panel of diverse prion strains, in a transgenic-mouse model and in its natural counterpart. The results showed very similar transmission properties in both the natural species and the transgenic-mouse model, demonstrating the key role of the PrP amino acid sequence in prion transmission susceptibility. However, differences in the PrPSc types propagated by Bv109M and BvPrP-Tg407 suggest that host factors other than PrPC modulate prion strain features. © 2016, American Society for Microbiology. All Rights Reserved.

Detalles Bibliográficos

Autores principales:	Espinosa, J. C., Nonno, R., Di Bari, M., Aguilar-Calvo, P., Pirisinu, L., Fernández-Borges, N., Vanni, I., Vaccari, G., Marín-Moreno, A., Frassanito, P., Lorenzo, P., Agrimi, U., Torres, J. M.
Formato:	journal article biblioteca
Idioma:	eng
Publicado:	2016
Acceso en línea:	http://hdl.handle.net/20.500.12792/5050
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