A comparison of marker-based estimators of inbreeding and inbreeding depression

The availability of genome-wide marker data allows estimation of inbreeding coefficients (F, the probability of identity-by-descent, IBD) and, in turn, estimation of the rate of inbreeding depression (ΔID). We investigated, by computer simulations, the accuracy of the most popular estimators of inbreeding based on molecular markers when computing F and ΔID in populations under random mating, equalization of parental contributions, and artificially selected populations. We assessed estimators described by Li and Horvitz (FLH1 and FLH2), VanRaden (FVR1 and FVR2), Yang and colleagues (FYA1 and FYA2), marker homozygosity (FHOM), runs of homozygosity (FROH) and estimates based on pedigree (FPED) in comparison with estimates obtained from IBD measures (FIBD).

Bibliographic Details

Main Authors:	Caballero, Armando, Fernández, Almudena, Villanueva, Beatriz, Toro, Miguel A.
Other Authors:	Caballero, Armando [0000-0001-7391-6974]
Format:	artículo biblioteca
Language:	English
Published:	Springer Nature 2022-12-27
Online Access:	http://hdl.handle.net/10261/304728 https://api.elsevier.com/content/abstract/scopus_id/85144787498
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