Plant and mammalian lignans A review of source, intake, metabolism, intestinal bacteria and health
Lignans are present in a wide range of foods consumed daily in the Western world such as flaxseed and other seeds, as well as vegetables, fruits and beverages such as coffee, tea and wine. Secoisolariciresinol diglucoside, a plant lignan, is metabolised to enterodiol and, then, to enterolactone. Matairesinol, another plant lignan, is also metabolised to enterolactone. Other dietary enterolignan precursors include lariciresinol, pinoresinol, medioresinol, syringaresinol, arctigenin and sesamin. Enterolignan-producing bacteria are common and accordingly enterolignans can be detected in the blood of most individuals; therefore, inter-individual differences in cell densities of the aforementioned bacteria may explain inter-individual differences in concentrations of enterolignan in blood. Research into the role of lignans in breast, colon and prostate cancer has generally shown they exert beneficial effects, although there are also some inconclusive studies or others that report negative effects. There are several possible mechanistic explanations for the observed bioactivities, including involvement in hormonal metabolism or availability, angiogenesis, anti-oxidation and gene suppression. Moreover, physiologically relevant concentrations of enterolignan have been shown to lead to "in vitro" and "in vivo" activation of oestrogen receptors. © 2012 Elsevier Ltd.
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| Format: | artículo de revisión biblioteca |
| Language: | English |
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Elsevier
2012
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| Subjects: | Lignans, Enterodiol, Enterolactone, Phyto-oestrogens, Enterolignan-producing bacteria, Flaxseed, |
| Online Access: | http://hdl.handle.net/20.500.12792/2294 http://hdl.handle.net/10261/292544 |
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