Antioxidant homeostasis is disturbed in fetuses with leptin-resistant genotypes A cross-sectional study

[Background], Leptin resistance is associated with lower reproductive efficiency, with deficiencies in embryo viability and growth leading to low prolificacy and high incidence of intrauterine growth restriction. [Objective], We aimed to investigate the underlying mechanisms of the leptin-resistance, evaluating the antioxidant homeostasis of leptin-resistant and lean swine fetuses. [Materials and Methods], The study included 70 plasma samples from fetuses at day 62 of gestation (mid-pregnancy), from breeds with (Iberian breed; n=35) and without leptin resistance (25% Large White x 25% Landrace x 50% Pietrain; n=35). The antioxidant status of the plasma samples was determined by photoinduced chemiluminescence whilst systemic oxidative stress was assessed determining plasma hydrogen peroxide concentration by enzimoimmunoassay. [Results], Plasma total antioxidant capacity was significantly lower in leptin-resistant fetuses (p=0.003), whilst systemic oxidative stress was increased (p=0.02). [Conclusion], Our results indicate key differences in the antioxidant status in pregnancies affected by leptin resistance.

Bibliographic Details

Main Authors:	Gonzalez-Añover, P., Torres-Rovira, L., García-Contreras, C., Vazquez-Gomez, M., Pesantez, J. L., Sanz-Fernandez, M. V., Astiz Blanco, Susana María, González De Bulnes, Antonio
Format:	artículo biblioteca
Language:	English
Published:	Knowledge E 2018
Subjects:	Animal models, Fetus,  Leptin,  Oxidative stress,  Pregnancy,
Online Access:	http://hdl.handle.net/20.500.12792/550 http://hdl.handle.net/10261/290785
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