A red-berry mixture as a nutraceutical: Detailed composition and neuronal protective effect

A red-berry mixture as a nutraceutical: Detailed composition and neuronal protective effect

This article belongs to the Special Issue Polyphenols and Human Being: From Epidemiology to Molecular Targets.

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Bibliographic Details
Main Authors: Carballeda-Sangiao, Noelia, Chamorro, Susana, Pascual-Teresa, Sonia de
Other Authors: Ministerio de Ciencia, Innovación y Universidades (España)
Format: artículo biblioteca
Language:English
Published: Multidisciplinary Digital Publishing Institute 2021
Subjects:Polyphenol, Red-berry, Anthocyanin, Antioxidant, Neuronal,
Online Access:http://hdl.handle.net/10261/266456
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100011033
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spelling dig-ictan-es-10261-2664562022-04-07T01:47:28Z A red-berry mixture as a nutraceutical: Detailed composition and neuronal protective effect Carballeda-Sangiao, Noelia Chamorro, Susana Pascual-Teresa, Sonia de Ministerio de Ciencia, Innovación y Universidades (España) Agencia Estatal de Investigación (España) Ministerio de Economía y Competitividad (España) European Commission Polyphenol Red-berry Anthocyanin Antioxidant Neuronal This article belongs to the Special Issue Polyphenols and Human Being: From Epidemiology to Molecular Targets. Recommendations towards increased consumption of fresh fruit and vegetables are well supported by epidemiological and clinical trials. However, in some specific cases, it is difficult to follow these recommendations and the use of nutraceuticals or, in the present work, a freeze-dried fruits mixture can be recommended in order to afford the optimal consumption of dietary polyphenols naturally present in fruits and vegetables. In this work we have carefully characterized a red-berry mixture in terms of polyphenol composition, encountering mainly anthocyanins, which account for a total of 2.8 mg/g as cyanidin-3-glucoside equivalents. Additionally, we have assayed the red-berry blend in a cell model of neurological damage by differentiating the cells and measuring the effect of red-berry polyphenols on cell viability and redox state by flow cytometry. The berry-fruit extract showed an inhibitory effect on differentiated SH-SY5Y ROS formation at a concentration as low as 250 µg/mL (33% inhibition). The results show the potential of this berry-fruit blend for its nutraceutical use in the prevention of the neurodegeneration associated with age or environmental agents. This research was funded by the Spanish Ministry of Science and Innovation through the National Program for Research Aimed at the Challenges of Society- RETOS program (Grant numbers: AGL2016-76832-R and PID2019-107009RB-I00). Peer reviewed 2022-04-06T11:43:57Z 2022-04-06T11:43:57Z 2021 artículo http://purl.org/coar/resource_type/c_6501 Molecules 26(11): 3210 (2021) http://hdl.handle.net/10261/266456 10.3390/molecules26113210 1420-3049 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100011033 34071973 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO//AGL2016-76832-R info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-107009RB-I00/ES/ALIMENTOS RICOS EN POLIFENOLES COMO ESTRATEGIA DE ENVEJECIMIENTO SALUDABLE Y SOSTENIBLE/ Publisher's version https://doi.org/10.3390/molecules26113210 Sí open Multidisciplinary Digital Publishing Institute
institution ICTAN ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-ictan-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del ICTAN España
language English
topic Polyphenol
Red-berry
Anthocyanin
Antioxidant
Neuronal
Polyphenol
Red-berry
Anthocyanin
Antioxidant
Neuronal
spellingShingle Polyphenol
Red-berry
Anthocyanin
Antioxidant
Neuronal
Polyphenol
Red-berry
Anthocyanin
Antioxidant
Neuronal
Carballeda-Sangiao, Noelia
Chamorro, Susana
Pascual-Teresa, Sonia de
A red-berry mixture as a nutraceutical: Detailed composition and neuronal protective effect
description This article belongs to the Special Issue Polyphenols and Human Being: From Epidemiology to Molecular Targets.
author2 Ministerio de Ciencia, Innovación y Universidades (España)
author_facet Ministerio de Ciencia, Innovación y Universidades (España)
Carballeda-Sangiao, Noelia
Chamorro, Susana
Pascual-Teresa, Sonia de
format artículo
topic_facet Polyphenol
Red-berry
Anthocyanin
Antioxidant
Neuronal
author Carballeda-Sangiao, Noelia
Chamorro, Susana
Pascual-Teresa, Sonia de
author_sort Carballeda-Sangiao, Noelia
title A red-berry mixture as a nutraceutical: Detailed composition and neuronal protective effect
title_short A red-berry mixture as a nutraceutical: Detailed composition and neuronal protective effect
title_full A red-berry mixture as a nutraceutical: Detailed composition and neuronal protective effect
title_fullStr A red-berry mixture as a nutraceutical: Detailed composition and neuronal protective effect
title_full_unstemmed A red-berry mixture as a nutraceutical: Detailed composition and neuronal protective effect
title_sort red-berry mixture as a nutraceutical: detailed composition and neuronal protective effect
publisher Multidisciplinary Digital Publishing Institute
publishDate 2021
url http://hdl.handle.net/10261/266456
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100011033
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