Evaluation of onion as a functional ingredient in the prevention of metabolic impairments associated to diet-induced hypercholesterolaemia using a multiplatform approach based on LC-MS, CE-MS and GC-MS

The preventive and modulating effects of onion in metabolites affected by a high-cholesterol diet and related to molecular pathway dysfunction were examined. Plasma obtained from 24 male Wistar rats after seven weeks of experimental feeding was analysed through a non-targeted multiplatform metabolomics approach based on LC-MS, CE-MS and GC-MS methods. A cross-comparison of the three metabolic profiles [I) control (C) group, II) high-cholesterol (HC) group and III) high-cholesterol enriched with onion (HCO) group] pointed out two sulphur metabolites, S-methyl-L-cysteine and S-methylcysteine sulphoxide, as markers of onion intake and evidenced the possibilities to regulate key metabolites. Thus, the methylation cycle, arginine and tryptophan pathways, the modulation of 3-methylhistidine, as well as the routes involved in the glycerophospholipids transformation have been highlighted. This study suggests that onion's biologically active compounds take a prominent role in ameliorating hypercholesterolaemia and related complications through the regulation of altered metabolic pathways.

Bibliographic Details

Main Authors:	González Peña, Diana, Dudzik, Danuta, Colina Coca, Clara, Ancos, Begoña de, García, Antonia, Barbas, Coral, Sánchez-Moreno, Concepción
Other Authors:	Ministerio de Economía y Competitividad (España)
Format:	artículo biblioteca
Published:	Elsevier 2015
Subjects:	Nutraceuticals, Onion metabolism, Plasma fingerprinting, Metabolomics, Functional foods, High-cholesterol diet,
Online Access:	http://hdl.handle.net/10261/133540 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100004837
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