Mammalian evolution of human cis-regulatory elements and transcription factor binding sites

[INTRODUCTION] Mammals, including humans, achieve high levels of organismal complexity largely due to how their proteins are regulated; characterizing the regulatory landscape of the human genome is a longstanding goal of modern biology. Contemporary approaches measure genome-wide biochemical signals, including chromatin accessibility, histone modifications, DNA methylation, and binding of ~1600 transcription factors (TFs) by the human genome. Using these methods, the ENCODE consortium defined almost one million candidate cis-regulatory elements (cCREs). Another approach uses evolutionary conservation to identify potential regulatory regions. We combine these approaches, examining how different functional classes of regulatory elements respond to evolutionary pressures.

Bibliographic Details

Main Authors:	Andrews, Gregory, Fan, Kaili, Pratt, Henry E., Phalke, Nishigandha, Zoonomia Consortium, Juan, David, Marqués-Bonet, Tomàs, Muntané, Gerard, Navarro, Arcadi, Serres-Armero, Aitor, Valenzuela, Alejandro, Karlsson, Elinor K., Lindblad-Toh, Kerstin, Gazal, Steven, Moore, Jill E., Weng, Zhiping
Other Authors:	National Institutes of Health (US)
Format:	artículo biblioteca
Language:	English
Published:	American Association for the Advancement of Science 2023-04-28
Online Access:	http://hdl.handle.net/10261/348476 http://dx.doi.org/10.13039/100000002
Tags:	Add Tag No Tags, Be the first to tag this record!