Integrating gene annotation with orthology inference at scale

Integrating gene annotation with orthology inference at scale

[INTRODUCTION] Comparative genomics provides valuable insights into gene function, phylogeny, molecular evolution, and associations between phenotypic and genomic differences. Such analyses require knowledge about which genes originated from a speciation event (orthologs) or from a duplication event (paralogs). Existing methods to detect orthologs in turn require knowledge of the location of genes in the genome (gene annotation), which is itself a challenging problem, resulting in a growing gap between sequenced and annotated genomes.

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Main Authors: Kirilenko, Bogdan M., Munegowda, Chetan, Osipova, Ekaterina, Jebb, David, Sharma, Virag, Blumer, Moritz, Morales, Ariadna E., Ahmed, Alexis-Walid, Kontopoulos, Dimitrios-Georgios, Hilgers, Leon, Lindblad-Toh, Kerstin, Karlsson, Elinor K., Zoonomia Consortium, Juan, David, Marqués-Bonet, Tomàs, Muntané, Gerard, Navarro, Arcadi, Serres-Armero, Aitor, Valenzuela, Alejandro, Hiller, Michael
Other Authors: LOEWE Centre for Translational Biodiversity Genomics
Format: artículo biblioteca
Language:English
Published: American Association for the Advancement of Science 2023-04-28
Online Access:http://hdl.handle.net/10261/348307
http://dx.doi.org/10.13039/501100004189
http://dx.doi.org/10.13039/501100001659
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http://hdl.handle.net/10261/348307
http://dx.doi.org/10.13039/501100004189
http://dx.doi.org/10.13039/501100001659

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