Haplotypes-based genetic analysis: benefits and challenges
The increasing availability of Single Nucleotide Polymorphisms (SNPs) discovered by Next Generation Sequencing will enable a range of new genetic analyses in crops, which was not possible before. Concomitantly, researchers will face the challenge of handling large data sets at the whole-genome level. By grouping thousands of SNPs into a few hundred haplotype blocks, complexity of the data can be reduced with fewer statistical tests and a lower probability of spurious associations. Owing to the strong genome structure present in breeding lines of most crops, the deployment of haplotypes could be a powerful complement to improve efficiency of marker-assisted and genomic selection. This review describes in brief the commonly used approaches to construct haplotype blocks and some examples in animals and crops are cited where haplotype-based dissection of traits were proven beneficial. Some important considerations and facts while working with haplotypes in crops are reviewed at the end.
| Main Authors: | , |
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| Format: | Article biblioteca |
| Language: | English |
| Published: |
Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences
2019
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| Subjects: | GENOMES, MARKER-ASSISTED SELECTION, SINGLE NUCLEOTIDE POLYMORPHISM, |
| Online Access: | https://hdl.handle.net/10883/20691 |
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