Retinoic acid induces functionally suppressive Foxp3+RORγt+ T cells in vitro

[Introduction]: CD4+ T cells with regulatory function co-expressing Foxp3 and RORγt are linked to the development of oral tolerance towards innocuous food antigens in mice. This study aimed to discern the role played by IL-6 and retinoic acid (RA) in the in vitro generation of Foxp3+RORγt+ T cells and to investigate whether such cells have suppressive properties.

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Bibliographic Details
Main Authors: Martínez-Blanco, Mónica, Lozano-Ojalvo, Daniel, Pérez-Rodríguez, Leticia, Benedé, Sara, Molina, Elena, López-Fandiño, Rosina
Other Authors: Ministerio de Ciencia, Innovación y Universidades (España)
Format: artículo biblioteca
Language:English
Published: Frontiers Media 2021
Online Access:http://hdl.handle.net/10261/263380
http://dx.doi.org/10.13039/501100011033
http://dx.doi.org/10.13039/501100000780
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