In vitro bioaccessibility of bioactive compounds from citrus pomaces and orange pomace biscuits
This article belongs to the Special Issue Phytochemicals from Fruit and Vegetable By-Products and Wastes and Their Re-use.
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Multidisciplinary Digital Publishing Institute
2021
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| Subjects: | α-amylase, Anti-inflammatory activity, Antioxidant, Bioaccessibility, Citrus pomaces, Diabetes, Functional biscuits, Sensory analysis, α-glucosidase, |
| Online Access: | http://hdl.handle.net/10261/250657 http://dx.doi.org/10.13039/501100006048 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/100008725 http://dx.doi.org/10.13039/501100003339 |
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dig-cial-es-10261-2506572021-12-27T15:38:36Z In vitro bioaccessibility of bioactive compounds from citrus pomaces and orange pomace biscuits Fernández-Fernández, Adriana Maite Dellacassa, Eduardo Nardin, Tiziana Larcher, Roberto Gámbaro, Adriana Medrano-Fernandez, Alejandra Castillo, M. Dolores del Consejo Superior de Investigaciones Científicas (España) Agencia Estatal de Investigación (España) Ministerio de Ciencia, Innovación y Universidades (España) Agencia Nacional de Investigación e Innovación (Uruguay) Universidad de la República (Uruguay) Pedeciba (Uruguay) Programa de Desarrollo de las Ciencias Básicas (Uruguay) α-amylase Anti-inflammatory activity Antioxidant Bioaccessibility Citrus pomaces Diabetes Functional biscuits Sensory analysis α-glucosidase This article belongs to the Special Issue Phytochemicals from Fruit and Vegetable By-Products and Wastes and Their Re-use. The present investigation aimed to provide novel information on the chemical composition and in vitro bioaccessibility of bioactive compounds from raw citrus pomaces (mandarin varieties Clemenule and Ortanique and orange varieties Navel and Valencia). The effects of the baking process on their bioaccessibility was also assessed. Samples of pomaces and biscuits containing them as an ingredient were digested, mimicking the human enzymatic oral gastrointestinal digestion process, and the composition of the digests were analyzed. UHPLC-MS/MS results of the citrus pomaces flavonoid composition showed nobiletin, hesperidin/neohesperidin, tangeretin, heptamethoxyflavone, tetramethylscutellarein, and naringin/narirutin. The analysis of the digests indicated the bioaccessibility of compounds possessing antioxidant [6.6–11.0 mg GAE/g digest, 65.5–97.1 µmol Trolox Equivalents (TE)/g digest, and 135.5–214.8 µmol TE/g digest for total phenol content (TPC), ABTS, and ORAC-FL methods, respectively; significant reduction (p < 0.05) in Reactive Oxygen Species (ROS) formation under tert-butyl hydroperoxide (1 mM)-induced conditions in IEC-6 and CCD-18Co cells when pre-treated with concentrations 5–25 µg/mL of the digests], anti-inflammatory [significant reduction (p < 0.05) in nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 macrophages], and antidiabetic (IC50 3.97–11.42 mg/mL and 58.04–105.68 mg/mL for α-glucosidase and α-amylase inhibition capacities) properties in the citrus pomaces under study. In addition, orange pomace biscuits with the nutrition claims “no-added sugars” and “source of fiber”, as well as those with good sensory quality (6.9–6.7, scale 1–9) and potential health promoting properties, were obtained. In conclusion, the results supported the feasibility of citrus pomace as a natural sustainable source of health-promoting compounds such as flavonoids. Unfractionated orange pomace may be employed as a functional food ingredient for reducing the risk of pathophysiological processes linked to oxidative stress, inflammation, and carbohydrate metabolism, such as diabetes, among others. This research was funded by ANII (grant POS_NAC_2016_1_130292), program EMHE-CSIC (grant MHE-200003), PEDECIBA-UdelaR, CSIC (project 201970E117) and Ministerio de Ciencia e Innovación (project PID2019-111510RB-I00). Peer reviewed 2021-09-21T09:51:41Z 2021-09-21T09:51:41Z 2021 artículo http://purl.org/coar/resource_type/c_6501 Molecules 26(12): 3480 (2021) http://hdl.handle.net/10261/250657 10.3390/molecules26123480 1420-3049 http://dx.doi.org/10.13039/501100006048 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/100008725 http://dx.doi.org/10.13039/501100003339 34201056 en #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-111510RB-I00 Publisher's version https://doi.org/10.3390/molecules26123480 Sí open Multidisciplinary Digital Publishing Institute |
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α-amylase Anti-inflammatory activity Antioxidant Bioaccessibility Citrus pomaces Diabetes Functional biscuits Sensory analysis α-glucosidase α-amylase Anti-inflammatory activity Antioxidant Bioaccessibility Citrus pomaces Diabetes Functional biscuits Sensory analysis α-glucosidase |
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α-amylase Anti-inflammatory activity Antioxidant Bioaccessibility Citrus pomaces Diabetes Functional biscuits Sensory analysis α-glucosidase α-amylase Anti-inflammatory activity Antioxidant Bioaccessibility Citrus pomaces Diabetes Functional biscuits Sensory analysis α-glucosidase Fernández-Fernández, Adriana Maite Dellacassa, Eduardo Nardin, Tiziana Larcher, Roberto Gámbaro, Adriana Medrano-Fernandez, Alejandra Castillo, M. Dolores del In vitro bioaccessibility of bioactive compounds from citrus pomaces and orange pomace biscuits |
| description |
This article belongs to the Special Issue Phytochemicals from Fruit and Vegetable By-Products and Wastes and Their Re-use. |
| author2 |
Consejo Superior de Investigaciones Científicas (España) |
| author_facet |
Consejo Superior de Investigaciones Científicas (España) Fernández-Fernández, Adriana Maite Dellacassa, Eduardo Nardin, Tiziana Larcher, Roberto Gámbaro, Adriana Medrano-Fernandez, Alejandra Castillo, M. Dolores del |
| format |
artículo |
| topic_facet |
α-amylase Anti-inflammatory activity Antioxidant Bioaccessibility Citrus pomaces Diabetes Functional biscuits Sensory analysis α-glucosidase |
| author |
Fernández-Fernández, Adriana Maite Dellacassa, Eduardo Nardin, Tiziana Larcher, Roberto Gámbaro, Adriana Medrano-Fernandez, Alejandra Castillo, M. Dolores del |
| author_sort |
Fernández-Fernández, Adriana Maite |
| title |
In vitro bioaccessibility of bioactive compounds from citrus pomaces and orange pomace biscuits |
| title_short |
In vitro bioaccessibility of bioactive compounds from citrus pomaces and orange pomace biscuits |
| title_full |
In vitro bioaccessibility of bioactive compounds from citrus pomaces and orange pomace biscuits |
| title_fullStr |
In vitro bioaccessibility of bioactive compounds from citrus pomaces and orange pomace biscuits |
| title_full_unstemmed |
In vitro bioaccessibility of bioactive compounds from citrus pomaces and orange pomace biscuits |
| title_sort |
in vitro bioaccessibility of bioactive compounds from citrus pomaces and orange pomace biscuits |
| publisher |
Multidisciplinary Digital Publishing Institute |
| publishDate |
2021 |
| url |
http://hdl.handle.net/10261/250657 http://dx.doi.org/10.13039/501100006048 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/100008725 http://dx.doi.org/10.13039/501100003339 |
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