In vitro bioaccessibility of extractable compounds from tannat grape skin possessing health promoting properties with potential to reduce the risk of diabetes
This article belongs to the Special Issue Grapes and their Derivatives in Functional Foods.
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| Format: | artículo biblioteca |
| Language: | English |
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Multidisciplinary Digital Publishing Institute
2020
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| Subjects: | Anti-inflammatory, α-glucosidase, Antioxidant, Diabetes, α-amylase, Bioaccessibility, |
| Online Access: | http://hdl.handle.net/10261/228664 http://dx.doi.org/10.13039/501100003339 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/100008725 |
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dig-cial-es-10261-2286642021-12-27T16:29:57Z In vitro bioaccessibility of extractable compounds from tannat grape skin possessing health promoting properties with potential to reduce the risk of diabetes Fernández-Fernández, Adriana Maite Iriondo-DeHond, Amaia Nardin, Tiziana Larcher, Roberto Dellacassa, Eduardo Medrano-Fernandez, Alejandra Castillo, M. Dolores del Agencia Nacional de Investigación e Innovación (Uruguay) Consejo Superior de Investigaciones Científicas (España) Ministerio de Ciencia, Innovación y Universidades (España) Agencia Estatal de Investigación (España) European Commission Anti-inflammatory α-glucosidase Antioxidant Diabetes α-amylase Bioaccessibility This article belongs to the Special Issue Grapes and their Derivatives in Functional Foods. Diabetes pathogenesis encompasses oxidative stress, inflammation, insulin malfunctioning and partial or total insulin secretion impairment, which leads to a constant hyperglycemia. Polyphenols are known to possess bioactive properties, being Tannat grape skin a natural and sustainable source of these compounds. The present study aimed to find out the bioaccessibility of health-promoting molecules composing a multifunctional extract from Tannat grape skin obtained under hydro-alcoholic-acid conditions. The identification of phenolic compounds in the samples was performed by ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS). Subsequently, the samples were in vitro digested mimicking the human oral gastrointestinal conditions and the bioactivity of the digest (antioxidant, anti-inflammatory and modulation of glucose metabolism) was assessed. Effect on glucose metabolism was estimated by measuring carbohydrases activity and the functionality of glucose transporters of small intestine cells in presence and absence of the digested extract. Flavonoids, phenolic acids and phenolic alcohols were the major phenol compounds detected in the extract. The bioaccessible compounds protected the intestinal cells and macrophages against the induced formation of reactive oxygen species (ROS) and nitric oxide (NO). In addition, glucose transporters were inhibited by the digested extract. In conclusion, the bioaccessible compounds of the extract, including phenols, modulated key biochemical events involved in the pathogenesis of diabetes such as oxidative stress, inflammation and glucose absorption. The extract was effective under prevention with co-administration conditions supporting its potential for either reducing the risk or treating this disease. This research was funded by Agencia Nacional de Investigación e Innovación (grant POS_NAC_2016_1_130292), program EMHE-CSIC (Enhancing Mobility between Latin America, Caribbean and the European Union in Health and Environment, grant MHE-200003), Programa de Desarrollo de las Ciencias Básicas (PEDECIBA-UDELAR), and PROYECTOS I + D + i (PID2019–111510RB-I00). Peer reviewed 2021-02-05T08:30:18Z 2021-02-05T08:30:18Z 2020 artículo http://purl.org/coar/resource_type/c_6501 http://hdl.handle.net/10261/228664 10.3390/foods9111575 2304-8158 http://dx.doi.org/10.13039/501100003339 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/100008725 33143027 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019–111510RB-I00 PID2019–111510RB-I00/AEI/10.13039/501100011033 Publisher's version https://doi.org/10.3390/foods9111575 Sí open Multidisciplinary Digital Publishing Institute |
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Anti-inflammatory α-glucosidase Antioxidant Diabetes α-amylase Bioaccessibility Anti-inflammatory α-glucosidase Antioxidant Diabetes α-amylase Bioaccessibility |
| spellingShingle |
Anti-inflammatory α-glucosidase Antioxidant Diabetes α-amylase Bioaccessibility Anti-inflammatory α-glucosidase Antioxidant Diabetes α-amylase Bioaccessibility Fernández-Fernández, Adriana Maite Iriondo-DeHond, Amaia Nardin, Tiziana Larcher, Roberto Dellacassa, Eduardo Medrano-Fernandez, Alejandra Castillo, M. Dolores del In vitro bioaccessibility of extractable compounds from tannat grape skin possessing health promoting properties with potential to reduce the risk of diabetes |
| description |
This article belongs to the Special Issue Grapes and their Derivatives in Functional Foods. |
| author2 |
Agencia Nacional de Investigación e Innovación (Uruguay) |
| author_facet |
Agencia Nacional de Investigación e Innovación (Uruguay) Fernández-Fernández, Adriana Maite Iriondo-DeHond, Amaia Nardin, Tiziana Larcher, Roberto Dellacassa, Eduardo Medrano-Fernandez, Alejandra Castillo, M. Dolores del |
| format |
artículo |
| topic_facet |
Anti-inflammatory α-glucosidase Antioxidant Diabetes α-amylase Bioaccessibility |
| author |
Fernández-Fernández, Adriana Maite Iriondo-DeHond, Amaia Nardin, Tiziana Larcher, Roberto Dellacassa, Eduardo Medrano-Fernandez, Alejandra Castillo, M. Dolores del |
| author_sort |
Fernández-Fernández, Adriana Maite |
| title |
In vitro bioaccessibility of extractable compounds from tannat grape skin possessing health promoting properties with potential to reduce the risk of diabetes |
| title_short |
In vitro bioaccessibility of extractable compounds from tannat grape skin possessing health promoting properties with potential to reduce the risk of diabetes |
| title_full |
In vitro bioaccessibility of extractable compounds from tannat grape skin possessing health promoting properties with potential to reduce the risk of diabetes |
| title_fullStr |
In vitro bioaccessibility of extractable compounds from tannat grape skin possessing health promoting properties with potential to reduce the risk of diabetes |
| title_full_unstemmed |
In vitro bioaccessibility of extractable compounds from tannat grape skin possessing health promoting properties with potential to reduce the risk of diabetes |
| title_sort |
in vitro bioaccessibility of extractable compounds from tannat grape skin possessing health promoting properties with potential to reduce the risk of diabetes |
| publisher |
Multidisciplinary Digital Publishing Institute |
| publishDate |
2020 |
| url |
http://hdl.handle.net/10261/228664 http://dx.doi.org/10.13039/501100003339 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/100008725 |
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