Linkage mapping of the bovine lysosomal alphamannosidase (MANB) gene

Linkage mapping of the bovine lysosomal alphamannosidase (MANB) gene

Lysosomal alpha-mannosidase is involved in the metabolism of mannoses in oligosaccharides in lysosomes. Deficiency of alpha-mannosidase, alpha-mannosidosis, has been described as an autosomal recessive storage disease in angus cattle, Galloway cattle and in cats. It is caused by non-synonymous substitutions in the encoding gene (MANB). Primers for MANB were designed from a bovine sequence (Gen Bank accession number U97686) and amplified a 316-bp fragment comprising intron 2 and adjacent exonic sequences. This paper discusses PCR primers, PCR conditions and polymorphism detection; and allele frequencies, inheritance and chromosomal location.

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Bibliographic Details
Main Authors: Gelhaus, A., Hanotte, Olivier H., Horstmann, R.D., Teale, A.J.
Format: Journal Article biblioteca
Language:English
Published: Wiley 1999-06
Subjects:bovidae, genes, genetic maps, lysozyme,
Online Access:https://hdl.handle.net/10568/30064
https://doi.org/10.1046/j.1365-2052.1999.00404-3.x
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spelling dig-cgspace-10568-300642023-09-09T02:43:35Z Linkage mapping of the bovine lysosomal alphamannosidase (MANB) gene Gelhaus, A. Hanotte, Olivier H. Horstmann, R.D. Teale, A.J. bovidae genes genetic maps lysozyme Lysosomal alpha-mannosidase is involved in the metabolism of mannoses in oligosaccharides in lysosomes. Deficiency of alpha-mannosidase, alpha-mannosidosis, has been described as an autosomal recessive storage disease in angus cattle, Galloway cattle and in cats. It is caused by non-synonymous substitutions in the encoding gene (MANB). Primers for MANB were designed from a bovine sequence (Gen Bank accession number U97686) and amplified a 316-bp fragment comprising intron 2 and adjacent exonic sequences. This paper discusses PCR primers, PCR conditions and polymorphism detection; and allele frequencies, inheritance and chromosomal location. 1999-06 2013-06-11T09:26:04Z 2013-06-11T09:26:04Z Journal Article Animal Genetics;30: 227-228 0268-9146 https://hdl.handle.net/10568/30064 https://doi.org/10.1046/j.1365-2052.1999.00404-3.x en Copyrighted; all rights reserved Limited Access p. 227-228 Wiley Animal Genetics
institution CGIAR
collection DSpace
country Francia
countrycode FR
component Bibliográfico
access En linea
databasecode dig-cgspace
tag biblioteca
region Europa del Oeste
libraryname Biblioteca del CGIAR
language English
topic bovidae
genes
genetic maps
lysozyme
bovidae
genes
genetic maps
lysozyme
spellingShingle bovidae
genes
genetic maps
lysozyme
bovidae
genes
genetic maps
lysozyme
Gelhaus, A.
Hanotte, Olivier H.
Horstmann, R.D.
Teale, A.J.
Linkage mapping of the bovine lysosomal alphamannosidase (MANB) gene
description Lysosomal alpha-mannosidase is involved in the metabolism of mannoses in oligosaccharides in lysosomes. Deficiency of alpha-mannosidase, alpha-mannosidosis, has been described as an autosomal recessive storage disease in angus cattle, Galloway cattle and in cats. It is caused by non-synonymous substitutions in the encoding gene (MANB). Primers for MANB were designed from a bovine sequence (Gen Bank accession number U97686) and amplified a 316-bp fragment comprising intron 2 and adjacent exonic sequences. This paper discusses PCR primers, PCR conditions and polymorphism detection; and allele frequencies, inheritance and chromosomal location.
format Journal Article
topic_facet bovidae
genes
genetic maps
lysozyme
author Gelhaus, A.
Hanotte, Olivier H.
Horstmann, R.D.
Teale, A.J.
author_facet Gelhaus, A.
Hanotte, Olivier H.
Horstmann, R.D.
Teale, A.J.
author_sort Gelhaus, A.
title Linkage mapping of the bovine lysosomal alphamannosidase (MANB) gene
title_short Linkage mapping of the bovine lysosomal alphamannosidase (MANB) gene
title_full Linkage mapping of the bovine lysosomal alphamannosidase (MANB) gene
title_fullStr Linkage mapping of the bovine lysosomal alphamannosidase (MANB) gene
title_full_unstemmed Linkage mapping of the bovine lysosomal alphamannosidase (MANB) gene
title_sort linkage mapping of the bovine lysosomal alphamannosidase (manb) gene
publisher Wiley
publishDate 1999-06
url https://hdl.handle.net/10568/30064
https://doi.org/10.1046/j.1365-2052.1999.00404-3.x
work_keys_str_mv AT gelhausa linkagemappingofthebovinelysosomalalphamannosidasemanbgene
AT hanotteolivierh linkagemappingofthebovinelysosomalalphamannosidasemanbgene
AT horstmannrd linkagemappingofthebovinelysosomalalphamannosidasemanbgene
AT tealeaj linkagemappingofthebovinelysosomalalphamannosidasemanbgene
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