Characterisation of a monoclonal antibody recognising the CD3 epsilon chain of the bovine T cell receptor complex
The characterisation of a monoclonal antibody (mAb), designated MM1A, which reacts with an antigen molecule on the surface of bovine alfa beta and gama delta TcR+ T cells is described. The mAb immunoprecipitated a series of polypeptides of 21 kDa, 22 kDa, 36 kDa and 44 kDa which is consistent with it recognising the TcR/CD3 complex. COS cells, transfected with a cDNA encoding the bovine CD3e chain, reacted with mAb MM1A indicating that the epitope recognised is on the chain of the complex and confirming the mAb recognised bovine CD3.
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| Main Authors: | , , , |
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| Format: | Journal Article biblioteca |
| Language: | English |
| Published: |
Elsevier
1998-02
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| Subjects: | bovinae, monoclonal antibodies, genetic transformation, immunology, |
| Online Access: | https://hdl.handle.net/10568/29861 https://doi.org/10.1016/S0165-2427(97)00087-1 |
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