Extreme-QTL mapping of monepantel resistance in Haemonchus contortus.

Extreme-QTL mapping of monepantel resistance in Haemonchus contortus.

Haemonchus contortus, a gastrointestinal nematode parasite of sheep, is mainly controlled by anthelmintics; the occurrence of anthelmintic resistance leads to treatment failures and increases economic burden. Because molecular mechanisms involved in drug resistance can be elucidated by genomic studies, an extreme quantitative trait locus (X-QTL) mapping approach was used to identify co-segregation of the resistance phenotype with genetic markers to detect the genome-wide variants associated with monepantel resistance in H. contortus.

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Bibliographic Details
Main Authors: NICIURA, S. C. M., TIZIOTO, P. C., MORAES, C. V., CRUVINEL, G. G., ALBUQUERQUE, A. C. A. de, SANTANA, R. C. M., CHAGAS, A. C. de S., ESTEVES, S. N., BENAVIDES, M. V., AMARANTE, A. F. T. do
Other Authors: SIMONE CRISTINA MEO NICIURA, CPPSE; Polyana Cristine Tizioto, NGS Soluções Genômicas; Caroline Valério Moraes, UFSCar; Giovanna Gabrielle Cruvinel, UNICEP; Ana Cláudia Alexandre de Albuquerque, FMVZ-UNESP; RAUL COSTA MASCARENHAS SANTANA, CPPSE; ANA CAROLINA DE SOUZA CHAGAS, CPPSE; SERGIO NOVITA ESTEVES, CPPSE; MAGDA VIEIRA BENAVIDES, CPPSUL; Alessandro Francisco Talamini do Amarante, IBB-UNESP.
Format: Artigo de periódico biblioteca
Language:English
eng
Published: 2019-08-20
Subjects:Anthelmintic resistance, Genome sequencing, Sheep gastrointestinal nematodes, F2 mapping, Drug resistance,
Online Access:http://www.alice.cnptia.embrapa.br/alice/handle/doc/1111456
https://doi.org/10.1186/s13071-019-3663-9
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http://www.alice.cnptia.embrapa.br/alice/handle/doc/1111456
https://doi.org/10.1186/s13071-019-3663-9

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