A comprehensive manually-curated compendium of bovine transcription factors.

Transcription factors (TFs) are pivotal regulatory proteins that control gene expression in a contextdependent and tissue-specific manner. In contrast to human, where comprehensive curated TF collections exist, bovine TFs are only rudimentary recorded and characterized. In this article, we present a manually-curated compendium of 865 sequence-specific DNA-binding bovines TFs, which we analyzed for domain family distribution, evolutionary conservation, and tissue-specific expression. In addition, we provide a list of putative transcription cofactors derived from known interactions with the identified TFs. Since there is a general lack of knowledge concerning the regulation of gene expression in cattle, the curated list of TF should provide a basis for an improved comprehension of regulatory mechanisms that are specific to the species.

Bibliographic Details

Main Authors:	SOUZA, M. M. de, ZERLOTINI NETO, A., GEISTLINGER, L., TIZIOTO, P. C., TAYLOR, J. F., ROCHA, M. I. P., DINIZ, W. J. S., COUTINHO, L. L., REGITANO, L. C. de A.
Other Authors:	MARCELA M. DE SOUZA, UFSCar; ADHEMAR ZERLOTINI NETO, CNPTIA; LUDWIG GEISTLINGER, CPPSE; POLYANA C. TIZIOTO, NGS Genomic Solution; JEREMY F. TAYLOR, University of Missouri; MARINA I. P. ROCHA, UFSCar; WELLISON J. S. DINIZ, UFSCar; LUIZ L. COUTINHO, USP; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE.
Format:	Artigo de periódico biblioteca
Language:	English eng
Published:	2018-12-20
Subjects:	DNA bovino, Expressão gênica, Gene expression in cattle, Gene expression regulation,
Online Access:	http://www.alice.cnptia.embrapa.br/alice/handle/doc/1102174
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