In vitro and in vivo anti-malarial activity of plants from the Brazilian Amazon.

The anti-malarials quinine and artemisinin were isolated from traditionally used plants (Cinchona spp. and Artemisia annua, respectively). The synthetic quinoline anti-malarials (e.g. chloroquine) and semi-synthetic artemisinin derivatives (e.g. artesunate) were developed based on these natural products. Malaria is endemic to the Amazon region where Plasmodium falciparum and Plasmodium vivax drug-resistance is of concern. There is an urgent need for new anti-malarials. Traditionally used Amazonian plants may provide new treatments for drug-resistant P. vivax and P. falciparum. Herein, the in vitro and in vivo antiplasmodial activity and cytotoxicity of medicinal plant extracts were investigated.

Bibliographic Details

Main Authors:	LIMA, R. B. S., SILVA, L. F. R. e, MELO, M. R. S., COSTA, J. S., PICANÇO, N. S., LIMA, E. S., VASCONCELLOS, M. C., BOLETI, A. P. A., SANTOS, J. M. P., AMORIM, R. C. N., CHAVES, F. C. M., COUTINHO, J. P., TADEI, W. P., KRETTLI, A. U., POHLIT, A. M.
Other Authors:	Renata B. S. Lima; Luiz F. Rocha e Silva; Marcia R. S. Melo; Jaqueline S. Costa; Neila S. Picanço; Emerson S. Lima; Marne C. Vasconcellos; Ana Paula A. Boleti; Jakeline M. P. Santos; Rodrigo C. N. Amorim; FRANCISCO CELIO MAIA CHAVES, CPAA; Julia P. Coutinho; Wanderli P. Tadei, INPA; Antoniana U. Krettli; Adrian M. Pohlit.
Format:	Separatas biblioteca
Language:	English eng
Published:	2015-12-21
Subjects:	Antiplasmodial, Cytotoxic, Andropogon leucostachyus, Xylopia amazonica, Zanthoxylum djalma-batistae., Anacardium Occidentale, Paullinia Cupana., Croton cajucara, Plasmodium berghei, Plasmodium falciparum, malaria.,
Online Access:	http://www.alice.cnptia.embrapa.br/alice/handle/doc/1032178
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