Bacterial antibiotic resistance by efflux pumps. multidrug resistance impact

Bacterial antibiotic resistance by efflux pumps. multidrug resistance impact

Bacterial antimicrobial resistance is a serious problem worldwide. Several mechanisms of resistance have been described, among which are efflux pump systems. These systems are constituted by protein transporters organized in superfamilies and ubiquitously distributed among eukaryote and prokaryote organisms. The genes encoding efflux pumps can be found in the bacterial chromosome or in transmissible genetic elements such as plasmids. Some efflux pump systems may transport structurally dissimilar antimicrobial agents (Multiple Drug Resistance: MDR). Antibiotic efflux in association with other resistance mechanisms could confer high resistance level in commensal and pathogen bacteria causing consequent therapeutic failures. Due to the increasing importance of this microbial defense mechanism, several strategies to modify and reverse bacterial resistance by efflux pumps are currently being explored.

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Main Authors: Marchetti, ML, Errecalde, J, Mestorino, N
Format: Digital revista
Language:spa
Published: Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata 2011
Online Access:https://revistas.unlp.edu.ar/analecta/article/view/12392
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spelling rev-analecta-ar-article-123922021-07-08T13:55:04Z Bacterial antibiotic resistance by efflux pumps. multidrug resistance impact Resistencia bacteriana a los antimicrobianos ocasionada por bombas de eflujo. Impacto en la multiresistencia Marchetti, ML Errecalde, J Mestorino, N multirresistencia antimicrobiano bomba de eflujo bacterias multidrug resistance antimicrobial efflux pump bacteria Bacterial antimicrobial resistance is a serious problem worldwide. Several mechanisms of resistance have been described, among which are efflux pump systems. These systems are constituted by protein transporters organized in superfamilies and ubiquitously distributed among eukaryote and prokaryote organisms. The genes encoding efflux pumps can be found in the bacterial chromosome or in transmissible genetic elements such as plasmids. Some efflux pump systems may transport structurally dissimilar antimicrobial agents (Multiple Drug Resistance: MDR). Antibiotic efflux in association with other resistance mechanisms could confer high resistance level in commensal and pathogen bacteria causing consequent therapeutic failures. Due to the increasing importance of this microbial defense mechanism, several strategies to modify and reverse bacterial resistance by efflux pumps are currently being explored. La resistencia a los antimicrobianos representa un severo problema a nivel mundial. Se han descripto variados mecanismos de resistencia, entre los cuales se encuentran las bombas de eflujo. Estas son proteínas transportadoras de membrana, organizadas en superfamilias y distribuidas ubicuamente entre organismos procariotas y eucariotas. Los genes que codifican para las bombas de eflujo pueden estar localizados en el cromosoma bacteriano o bien en elementos genéticos transmisibles como los plásmidos. Algunos sistemas tienen la capacidad de expulsar antimicrobianos estructuralmente disímiles (Multiple Drug Resistance: MDR). La presencia de los mismos en combinación con otros mecanismos genera altos niveles de resistencia entre patógenos y comensales originando un consecuente fracaso terapéutico. Debido a la creciente importancia de este mecanismo de defensa microbiano se están investigando diversas estrategias para modificar y revertir la resistencia bacteriana por eflujo. Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata 2011-01-01 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Bibliographic Reviews Revisiones bibliográficas application/pdf https://revistas.unlp.edu.ar/analecta/article/view/12392 Analecta Veterinary; Vol. 31 No. 2 (2011): Analecta Veterinaria; 40-53 Analecta Veterinaria; Vol. 31 Núm. 2 (2011): Analecta Veterinaria; 40-53 Analecta Veterinaria; Vol. 31 No. 2 (2011): Analecta Veterinaria; 40-53 Analecta Veterinaria; v. 31 n. 2 (2011): Analecta Veterinaria; 40-53 1514-2590 0365-5148 spa https://revistas.unlp.edu.ar/analecta/article/view/12392/11184
institution UNLP AR
collection OJS
country Argentina
countrycode AR
component Revista
access En linea
databasecode rev-analecta-ar
tag revista
region America del Sur
libraryname Biblioteca de la Facultad de Ciencias Veterinarias de la UNLP Argentina
language spa
format Digital
author Marchetti, ML
Errecalde, J
Mestorino, N
spellingShingle Marchetti, ML
Errecalde, J
Mestorino, N
Bacterial antibiotic resistance by efflux pumps. multidrug resistance impact
author_facet Marchetti, ML
Errecalde, J
Mestorino, N
author_sort Marchetti, ML
title Bacterial antibiotic resistance by efflux pumps. multidrug resistance impact
title_short Bacterial antibiotic resistance by efflux pumps. multidrug resistance impact
title_full Bacterial antibiotic resistance by efflux pumps. multidrug resistance impact
title_fullStr Bacterial antibiotic resistance by efflux pumps. multidrug resistance impact
title_full_unstemmed Bacterial antibiotic resistance by efflux pumps. multidrug resistance impact
title_sort bacterial antibiotic resistance by efflux pumps. multidrug resistance impact
description Bacterial antimicrobial resistance is a serious problem worldwide. Several mechanisms of resistance have been described, among which are efflux pump systems. These systems are constituted by protein transporters organized in superfamilies and ubiquitously distributed among eukaryote and prokaryote organisms. The genes encoding efflux pumps can be found in the bacterial chromosome or in transmissible genetic elements such as plasmids. Some efflux pump systems may transport structurally dissimilar antimicrobial agents (Multiple Drug Resistance: MDR). Antibiotic efflux in association with other resistance mechanisms could confer high resistance level in commensal and pathogen bacteria causing consequent therapeutic failures. Due to the increasing importance of this microbial defense mechanism, several strategies to modify and reverse bacterial resistance by efflux pumps are currently being explored.
publisher Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata
publishDate 2011
url https://revistas.unlp.edu.ar/analecta/article/view/12392
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AT errecaldej bacterialantibioticresistancebyeffluxpumpsmultidrugresistanceimpact
AT mestorinon bacterialantibioticresistancebyeffluxpumpsmultidrugresistanceimpact
AT marchettiml resistenciabacterianaalosantimicrobianosocasionadaporbombasdeeflujoimpactoenlamultiresistencia
AT errecaldej resistenciabacterianaalosantimicrobianosocasionadaporbombasdeeflujoimpactoenlamultiresistencia
AT mestorinon resistenciabacterianaalosantimicrobianosocasionadaporbombasdeeflujoimpactoenlamultiresistencia
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