Could perinatal asphyxia induce a synaptopathy? : new highlights from an experimental model
Abstract: Birth asphyxia also termed perinatal asphyxia is an obstetric complication that strongly affects brain structure and function. Central nervous system is highly susceptible to oxidative damage caused by perinatal asphyxia while activation and maturity of the proper pathways are relevant to avoiding abnormal neural development. Perinatal asphyxia is associated with highmorbimortality in term and preterm neonates. Although several studies have demonstrated a variety of biochemical and molecular pathways involved in perinatal asphyxia physiopathology, little is known about the synaptic alterations induced by perinatal asphyxia. Nearly 25% of the newborns who survive perinatal asphyxia develop neurological disorders such as cerebral palsy and certain neurodevelopmental and learning disabilities where synaptic connectivity disturbances may be involved. Accordingly, here we review and discuss the association of possible synaptic dysfunctionwith perinatal asphyxia on the basis of updated evidence froman experimental model
Principais autores: | Herrera, María Inés, Otero Losada, Matilde, Udovin, Lucas Daniel, Kusnier, Carlos Federico, Kölliker Frers, Rodolfo, Souza, Wanderley de, Capani, Francisco |
---|---|
Formato: | Artículo biblioteca |
Idioma: | eng |
Publicado em: |
2017
|
Assuntos: | ASFIXIA NEONATAL, SISTEMA NERVIOSO, TRASTORNOS DEL NEURODESARROLLO, PSICOPATOLOGIA, NEUROPSICOLOGIA, BEBES, PSICOLOGIA, SINAPTOPATIA, |
Acesso em linha: | https://repositorio.uca.edu.ar/handle/123456789/6205 |
Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|
Registros relacionados
-
Synaptoprotection in perinatal asphyxia: an experimental approach
por: Herrera, María Inés, et al.
Publicado em: (2020) -
Palmitoylethanolamide ameliorates hippocampal damage and behavioral dysfunction after perinatal asphyxia in the immature rat brain
por: Herrera, María Inés, et al.
Publicado em: (2018) -
Partial reversal of striatal damage by palmitoylethanolamide administration following perinatal asphyxia
por: Udovin, Lucas Daniel, et al.
Publicado em: (2020) -
Correlative structural, biochemical and behavioral study in neuroprotection with palmitoylehanolamide after perinatal asphyxia in the immature brain
por: Herrera, María Inés, et al.
Publicado em: (2019) -
Palmitoiletanolamida como neuroprotector en un modelo experimental de asfixia perinatal: efectos conductuales : Aproximación desde la psicología comparada
por: Herrera, María Inés, et al.
Publicado em: (2020)