Dysregulation of neuronal nicotinic acetylcholine receptor–cholesterol crosstalk in autism spectrum disorder
Abstract: Autism spectrum disorder (ASD) is a set of complex neurodevelopmental diseases that include impaired social interaction, delayed and disordered language, repetitive or stereotypic behavior, restricted range of interests, and altered sensory processing. The underlying causes of the core symptoms remain unclear, as are the factors that trigger their onset. Given the complexity and heterogeneity of the clinical phenotypes, a constellation of genetic, epigenetic, environmental, and immunological factors may be involved. The lack of appropriate biomarkers for the evaluation of neurodevelopmental disorders makes it difficult to assess the contribution of early alterations in neurochemical processes and neuroanatomical and neurodevelopmental factors to ASD. Abnormalities in the cholinergic system in various regions of the brain and cerebellum are observed in ASD, and recently altered cholesterol metabolism has been implicated at the initial stages of the disease. Given the multiple effects of the neutral lipid cholesterol on the paradigm rapid ligand-gated ion channel, the nicotinic acetylcholine receptor, we explore in this review the possibility that the dysregulation of nicotinic receptor-cholesterol crosstalk plays a role in some of the neurological alterations observed in ASD.
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Frontiers Media
2021
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Subjects: | AUTISMO, TRASTORNO DEL ESPECTRO AUTISTA, NEUROCIENCIA, |
Online Access: | https://repositorio.uca.edu.ar/handle/123456789/14729 |
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oai:ucacris:123456789-147292022-08-23T11:51:51Z Dysregulation of neuronal nicotinic acetylcholine receptor–cholesterol crosstalk in autism spectrum disorder Vallés, Ana Sofía Barrantes, Francisco José AUTISMO TRASTORNO DEL ESPECTRO AUTISTA NEUROCIENCIA Abstract: Autism spectrum disorder (ASD) is a set of complex neurodevelopmental diseases that include impaired social interaction, delayed and disordered language, repetitive or stereotypic behavior, restricted range of interests, and altered sensory processing. The underlying causes of the core symptoms remain unclear, as are the factors that trigger their onset. Given the complexity and heterogeneity of the clinical phenotypes, a constellation of genetic, epigenetic, environmental, and immunological factors may be involved. The lack of appropriate biomarkers for the evaluation of neurodevelopmental disorders makes it difficult to assess the contribution of early alterations in neurochemical processes and neuroanatomical and neurodevelopmental factors to ASD. Abnormalities in the cholinergic system in various regions of the brain and cerebellum are observed in ASD, and recently altered cholesterol metabolism has been implicated at the initial stages of the disease. Given the multiple effects of the neutral lipid cholesterol on the paradigm rapid ligand-gated ion channel, the nicotinic acetylcholine receptor, we explore in this review the possibility that the dysregulation of nicotinic receptor-cholesterol crosstalk plays a role in some of the neurological alterations observed in ASD. 2022-08-22T19:51:03Z 2022-08-22T19:51:03Z 2021 Artículo Vallés, A. S.; Barrantes, F. J. Dysregulation of neuronal nicotinic acetylcholine receptor–cholesterol crosstalk in autism spectrum disorder [en línea]. Frontiers in Molecular Neuroscience. 2021. 14 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14729 1662-5099 https://repositorio.uca.edu.ar/handle/123456789/14729 10.3389/fnmol.2021.744597 34803605 eng Acceso abierto http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Frontiers Media Frontiers in Molecular Neuroscience. 2021, 14 |
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AUTISMO TRASTORNO DEL ESPECTRO AUTISTA NEUROCIENCIA AUTISMO TRASTORNO DEL ESPECTRO AUTISTA NEUROCIENCIA |
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AUTISMO TRASTORNO DEL ESPECTRO AUTISTA NEUROCIENCIA AUTISMO TRASTORNO DEL ESPECTRO AUTISTA NEUROCIENCIA Vallés, Ana Sofía Barrantes, Francisco José Dysregulation of neuronal nicotinic acetylcholine receptor–cholesterol crosstalk in autism spectrum disorder |
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Abstract: Autism spectrum disorder (ASD) is a set of complex neurodevelopmental diseases that include impaired social interaction, delayed and disordered language, repetitive or stereotypic behavior, restricted range of interests, and altered sensory processing. The underlying causes of the core symptoms remain unclear, as are the factors that trigger their onset. Given the complexity and heterogeneity of the clinical phenotypes, a constellation of genetic, epigenetic, environmental, and immunological factors may be involved. The lack of appropriate biomarkers for the evaluation of neurodevelopmental disorders makes it difficult to assess the contribution of early alterations in neurochemical processes and neuroanatomical and neurodevelopmental factors to ASD. Abnormalities in the cholinergic system in various regions of the brain and cerebellum are observed in ASD, and recently altered cholesterol metabolism has been implicated at the initial stages of the disease. Given the multiple effects of the neutral lipid cholesterol on the paradigm rapid ligand-gated ion channel, the nicotinic acetylcholine receptor, we explore in this review the possibility that the dysregulation of nicotinic receptor-cholesterol crosstalk plays a role in some of the neurological alterations observed in ASD. |
format |
Artículo |
topic_facet |
AUTISMO TRASTORNO DEL ESPECTRO AUTISTA NEUROCIENCIA |
author |
Vallés, Ana Sofía Barrantes, Francisco José |
author_facet |
Vallés, Ana Sofía Barrantes, Francisco José |
author_sort |
Vallés, Ana Sofía |
title |
Dysregulation of neuronal nicotinic acetylcholine receptor–cholesterol crosstalk in autism spectrum disorder |
title_short |
Dysregulation of neuronal nicotinic acetylcholine receptor–cholesterol crosstalk in autism spectrum disorder |
title_full |
Dysregulation of neuronal nicotinic acetylcholine receptor–cholesterol crosstalk in autism spectrum disorder |
title_fullStr |
Dysregulation of neuronal nicotinic acetylcholine receptor–cholesterol crosstalk in autism spectrum disorder |
title_full_unstemmed |
Dysregulation of neuronal nicotinic acetylcholine receptor–cholesterol crosstalk in autism spectrum disorder |
title_sort |
dysregulation of neuronal nicotinic acetylcholine receptor–cholesterol crosstalk in autism spectrum disorder |
publisher |
Frontiers Media |
publishDate |
2021 |
url |
https://repositorio.uca.edu.ar/handle/123456789/14729 |
work_keys_str_mv |
AT vallesanasofia dysregulationofneuronalnicotinicacetylcholinereceptorcholesterolcrosstalkinautismspectrumdisorder AT barrantesfranciscojose dysregulationofneuronalnicotinicacetylcholinereceptorcholesterolcrosstalkinautismspectrumdisorder |
_version_ |
1756276617671344128 |