Amyloid and anatomical correlates of executive functioning in middle-aged offspring of patients with late-onset Alzheimer's disease
Abstract: A traditional hallmark of cognitive impairment associated with late-onset Alzheimer´s disease (LOAD) is episodic memory impairment. However, early alterations have been identified in brain regions associated with executive function in asymptomatic, middle-age offspring of patients with LOAD (O-LOAD) compared to those with no family history. We hypothesized that executive function among O-LOAD would correlate with structural and amyloid brain imaging differently from those without a family history of LOAD (control subjects, CS). Executive function, cortical thickness, and in-vivo Aβ deposits were quantified in 30 O-LOAD and 25 CS. Associations were observed among O-LOAD only. Cortical thickness in the left lateral orbitofrontal cortex was positively associated with Design Fluency. The Stroop Color and Word Test, correlated positively with right rostral mid-frontal cortex thickness. Trails Making Test-B was inversely related to left medial orbitofrontal thickness. Tower of London total time was positively associated with β-amyloid deposition in the right precuneus. These results support previous evidence that early executive dysfunction might reflect subtle, early changes in persons at risk of LOAD and suggests that executive function alterations deserve further exploration in the LOAD literature.
Main Authors: | , , , , , , , , , |
---|---|
Format: | Artículo biblioteca |
Language: | eng |
Published: |
Elsevier
2021
|
Subjects: | ENFERMEDAD DE ALZHEIMER, RESONANCIA MAGNETICA NUCLEAR, BIOMARCADORES, PET-PiB, FUNCIONES EJECUTIVAS, |
Online Access: | https://repositorio.uca.edu.ar/handle/123456789/14018 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
oai:ucacris:123456789-14018 |
---|---|
record_format |
koha |
spelling |
oai:ucacris:123456789-140182022-10-28T16:00:46Z Amyloid and anatomical correlates of executive functioning in middle-aged offspring of patients with late-onset Alzheimer's disease Duarte Abritta, Bárbara Sánchez, Stella Maris Abulafia, Carolina Andrea Gustafson, Deborah R. Vázquez, Silvia Sevlever, Gustavo Castro, Mariana N. Fiorentini, Leticia Villarreal, Mirta F. Guinjoan, Salvador M. ENFERMEDAD DE ALZHEIMER RESONANCIA MAGNETICA NUCLEAR BIOMARCADORES PET-PiB FUNCIONES EJECUTIVAS Abstract: A traditional hallmark of cognitive impairment associated with late-onset Alzheimer´s disease (LOAD) is episodic memory impairment. However, early alterations have been identified in brain regions associated with executive function in asymptomatic, middle-age offspring of patients with LOAD (O-LOAD) compared to those with no family history. We hypothesized that executive function among O-LOAD would correlate with structural and amyloid brain imaging differently from those without a family history of LOAD (control subjects, CS). Executive function, cortical thickness, and in-vivo Aβ deposits were quantified in 30 O-LOAD and 25 CS. Associations were observed among O-LOAD only. Cortical thickness in the left lateral orbitofrontal cortex was positively associated with Design Fluency. The Stroop Color and Word Test, correlated positively with right rostral mid-frontal cortex thickness. Trails Making Test-B was inversely related to left medial orbitofrontal thickness. Tower of London total time was positively associated with β-amyloid deposition in the right precuneus. These results support previous evidence that early executive dysfunction might reflect subtle, early changes in persons at risk of LOAD and suggests that executive function alterations deserve further exploration in the LOAD literature. 2022-05-24T13:29:02Z 2022-05-24T13:29:02Z 2021 Artículo Duarte Abritta, B. et al. Amyloid and anatomical correlates of executive functioning in middle-aged offspring of patients with late-onset Alzheimer's disease [en línea]. Postprint del artículo publicado en: Psychiatry Research: Neuroimaging. 2021, 316. doi: https://doi.org/10.1016/j.pscychresns.2021.111342. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14018 0925-4927 https://repositorio.uca.edu.ar/handle/123456789/14018 10.1016/j.pscychresns.2021.111342 eng Acceso abierto http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Elsevier Psychiatry Research: Neuroimaging Vol.316, 2021 |
institution |
UCA |
collection |
DSpace |
country |
Argentina |
countrycode |
AR |
component |
Bibliográfico |
access |
En linea |
databasecode |
dig-uca |
tag |
biblioteca |
region |
America del Sur |
libraryname |
Sistema de bibliotecas de la UCA |
language |
eng |
topic |
ENFERMEDAD DE ALZHEIMER RESONANCIA MAGNETICA NUCLEAR BIOMARCADORES PET-PiB FUNCIONES EJECUTIVAS ENFERMEDAD DE ALZHEIMER RESONANCIA MAGNETICA NUCLEAR BIOMARCADORES PET-PiB FUNCIONES EJECUTIVAS |
spellingShingle |
ENFERMEDAD DE ALZHEIMER RESONANCIA MAGNETICA NUCLEAR BIOMARCADORES PET-PiB FUNCIONES EJECUTIVAS ENFERMEDAD DE ALZHEIMER RESONANCIA MAGNETICA NUCLEAR BIOMARCADORES PET-PiB FUNCIONES EJECUTIVAS Duarte Abritta, Bárbara Sánchez, Stella Maris Abulafia, Carolina Andrea Gustafson, Deborah R. Vázquez, Silvia Sevlever, Gustavo Castro, Mariana N. Fiorentini, Leticia Villarreal, Mirta F. Guinjoan, Salvador M. Amyloid and anatomical correlates of executive functioning in middle-aged offspring of patients with late-onset Alzheimer's disease |
description |
Abstract:
A traditional hallmark of cognitive impairment associated with late-onset Alzheimer´s disease (LOAD) is episodic memory impairment. However, early alterations have been identified in brain regions associated with executive function in asymptomatic, middle-age offspring of patients with LOAD (O-LOAD) compared to those with no family history. We hypothesized that executive function among O-LOAD would correlate with structural and amyloid brain imaging differently from those without a family history of LOAD (control subjects, CS). Executive function, cortical thickness, and in-vivo Aβ deposits were quantified in 30 O-LOAD and 25 CS. Associations were observed among O-LOAD only. Cortical thickness in the left lateral orbitofrontal cortex was positively associated with Design Fluency. The Stroop Color and Word Test, correlated positively with right rostral mid-frontal cortex thickness. Trails Making Test-B was inversely related to left medial orbitofrontal thickness. Tower of London total time was positively associated with β-amyloid deposition in the right precuneus. These results support previous evidence that early executive dysfunction might reflect subtle, early changes in persons at risk of LOAD and suggests that executive function alterations deserve further exploration in the LOAD literature. |
format |
Artículo |
topic_facet |
ENFERMEDAD DE ALZHEIMER RESONANCIA MAGNETICA NUCLEAR BIOMARCADORES PET-PiB FUNCIONES EJECUTIVAS |
author |
Duarte Abritta, Bárbara Sánchez, Stella Maris Abulafia, Carolina Andrea Gustafson, Deborah R. Vázquez, Silvia Sevlever, Gustavo Castro, Mariana N. Fiorentini, Leticia Villarreal, Mirta F. Guinjoan, Salvador M. |
author_facet |
Duarte Abritta, Bárbara Sánchez, Stella Maris Abulafia, Carolina Andrea Gustafson, Deborah R. Vázquez, Silvia Sevlever, Gustavo Castro, Mariana N. Fiorentini, Leticia Villarreal, Mirta F. Guinjoan, Salvador M. |
author_sort |
Duarte Abritta, Bárbara |
title |
Amyloid and anatomical correlates of executive functioning in middle-aged offspring of patients with late-onset Alzheimer's disease |
title_short |
Amyloid and anatomical correlates of executive functioning in middle-aged offspring of patients with late-onset Alzheimer's disease |
title_full |
Amyloid and anatomical correlates of executive functioning in middle-aged offspring of patients with late-onset Alzheimer's disease |
title_fullStr |
Amyloid and anatomical correlates of executive functioning in middle-aged offspring of patients with late-onset Alzheimer's disease |
title_full_unstemmed |
Amyloid and anatomical correlates of executive functioning in middle-aged offspring of patients with late-onset Alzheimer's disease |
title_sort |
amyloid and anatomical correlates of executive functioning in middle-aged offspring of patients with late-onset alzheimer's disease |
publisher |
Elsevier |
publishDate |
2021 |
url |
https://repositorio.uca.edu.ar/handle/123456789/14018 |
work_keys_str_mv |
AT duarteabrittabarbara amyloidandanatomicalcorrelatesofexecutivefunctioninginmiddleagedoffspringofpatientswithlateonsetalzheimersdisease AT sanchezstellamaris amyloidandanatomicalcorrelatesofexecutivefunctioninginmiddleagedoffspringofpatientswithlateonsetalzheimersdisease AT abulafiacarolinaandrea amyloidandanatomicalcorrelatesofexecutivefunctioninginmiddleagedoffspringofpatientswithlateonsetalzheimersdisease AT gustafsondeborahr amyloidandanatomicalcorrelatesofexecutivefunctioninginmiddleagedoffspringofpatientswithlateonsetalzheimersdisease AT vazquezsilvia amyloidandanatomicalcorrelatesofexecutivefunctioninginmiddleagedoffspringofpatientswithlateonsetalzheimersdisease AT sevlevergustavo amyloidandanatomicalcorrelatesofexecutivefunctioninginmiddleagedoffspringofpatientswithlateonsetalzheimersdisease AT castromarianan amyloidandanatomicalcorrelatesofexecutivefunctioninginmiddleagedoffspringofpatientswithlateonsetalzheimersdisease AT fiorentinileticia amyloidandanatomicalcorrelatesofexecutivefunctioninginmiddleagedoffspringofpatientswithlateonsetalzheimersdisease AT villarrealmirtaf amyloidandanatomicalcorrelatesofexecutivefunctioninginmiddleagedoffspringofpatientswithlateonsetalzheimersdisease AT guinjoansalvadorm amyloidandanatomicalcorrelatesofexecutivefunctioninginmiddleagedoffspringofpatientswithlateonsetalzheimersdisease |
_version_ |
1756276524352274432 |