How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach
Abstract: Recent advances in the area of the psycho-neuroendocrine-immunology have demonstrated that the inflammatory and immune reactions depend not only on immune factors, but also, they are under an intricate neuroendocrine regulation. In turn, the activity of the nervous and endocrine systems is affected by immune-inflammatory signals. Although most hormones and neuromodulators can potentially influence the immune function, main immunomodulatory properties seem to be exerted by opioid and cannabinoid systems. Brain opioid and cannabinoid systems are endocrinologically connected to the adrenal, and to the pineal gland, respectively. In addition, the neurohypophysis is also important for the neuroimmunomodulation through the release of vasopressin and oxytocin. Experimental evidence supports the conclusion that two fundamental functional circuits occur, including a brain opioid system-vasopressin-adrenal axis, characterized by a prevalent immunosuppressive activity, and a brain cannabinoid-oxytocin-pineal axis, which exerts an immunostimulatory role. The latter is relevant mainly for anticancer immunity. The opioid-adrenal functional axis is active in stress and depressive conditions, while the cannabinoid-pineal axis has been proven to be involved in pleasure perception and spiritual expansion of mind. The findings could explain the predisposition to severe systemic diseases played by stress and depression, and on the other hand the protective action of pleasure and spirituality in the onset of important pathologies. The clinical and therapeutic applications of these concepts may constitute a landmark for future Medicine.
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Crimson
2021
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Subjects: | CANNABINOIDES, CANCER, COVID-19, CITOQUINAS, MELATONINA, NEUROPROTECCION, INMUNOLOGIA, SISTEMA INMUNOLOGICO, |
Online Access: | https://repositorio.uca.edu.ar/handle/123456789/13679 |
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oai:ucacris:123456789-136792022-03-26T05:01:01Z How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach Lissoni, Paolo Brivio, Fernando Fumagalli, Luca Rovelli, Franco Colciago, Massimo Messina, Giusy Monzon, Alejandra Pelizzoni, Francesco Lissoni, Arianna Porro, Giorgio Di Fede, Giuseppe Cardinali, Daniel Pedro CANNABINOIDES CANCER COVID-19 CITOQUINAS MELATONINA NEUROPROTECCION INMUNOLOGIA SISTEMA INMUNOLOGICO Abstract: Recent advances in the area of the psycho-neuroendocrine-immunology have demonstrated that the inflammatory and immune reactions depend not only on immune factors, but also, they are under an intricate neuroendocrine regulation. In turn, the activity of the nervous and endocrine systems is affected by immune-inflammatory signals. Although most hormones and neuromodulators can potentially influence the immune function, main immunomodulatory properties seem to be exerted by opioid and cannabinoid systems. Brain opioid and cannabinoid systems are endocrinologically connected to the adrenal, and to the pineal gland, respectively. In addition, the neurohypophysis is also important for the neuroimmunomodulation through the release of vasopressin and oxytocin. Experimental evidence supports the conclusion that two fundamental functional circuits occur, including a brain opioid system-vasopressin-adrenal axis, characterized by a prevalent immunosuppressive activity, and a brain cannabinoid-oxytocin-pineal axis, which exerts an immunostimulatory role. The latter is relevant mainly for anticancer immunity. The opioid-adrenal functional axis is active in stress and depressive conditions, while the cannabinoid-pineal axis has been proven to be involved in pleasure perception and spiritual expansion of mind. The findings could explain the predisposition to severe systemic diseases played by stress and depression, and on the other hand the protective action of pleasure and spirituality in the onset of important pathologies. The clinical and therapeutic applications of these concepts may constitute a landmark for future Medicine. 2022-03-25T11:16:21Z 2022-03-25T11:16:21Z 2021 Artículo Lissoni, P. et al. How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach [en línea]. Novel approaches in cancer study. 2021, 5 (5). doi: 10.31031/NACS.2021.05.000622. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13679 2637-773X https://repositorio.uca.edu.ar/handle/123456789/13679 10.31031/NACS.2021.05.000622 eng Acceso abierto http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Crimson Novel approaches in cancer study. 2021, 5 (5) |
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CANNABINOIDES CANCER COVID-19 CITOQUINAS MELATONINA NEUROPROTECCION INMUNOLOGIA SISTEMA INMUNOLOGICO CANNABINOIDES CANCER COVID-19 CITOQUINAS MELATONINA NEUROPROTECCION INMUNOLOGIA SISTEMA INMUNOLOGICO |
spellingShingle |
CANNABINOIDES CANCER COVID-19 CITOQUINAS MELATONINA NEUROPROTECCION INMUNOLOGIA SISTEMA INMUNOLOGICO CANNABINOIDES CANCER COVID-19 CITOQUINAS MELATONINA NEUROPROTECCION INMUNOLOGIA SISTEMA INMUNOLOGICO Lissoni, Paolo Brivio, Fernando Fumagalli, Luca Rovelli, Franco Colciago, Massimo Messina, Giusy Monzon, Alejandra Pelizzoni, Francesco Lissoni, Arianna Porro, Giorgio Di Fede, Giuseppe Cardinali, Daniel Pedro How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach |
description |
Abstract: Recent advances in the area of the psycho-neuroendocrine-immunology have demonstrated that the
inflammatory and immune reactions depend not only on immune factors, but also, they are under an
intricate neuroendocrine regulation. In turn, the activity of the nervous and endocrine systems is affected
by immune-inflammatory signals. Although most hormones and neuromodulators can potentially
influence the immune function, main immunomodulatory properties seem to be exerted by opioid and
cannabinoid systems. Brain opioid and cannabinoid systems are endocrinologically connected to the
adrenal, and to the pineal gland, respectively. In addition, the neurohypophysis is also important for
the neuroimmunomodulation through the release of vasopressin and oxytocin. Experimental evidence
supports the conclusion that two fundamental functional circuits occur, including a brain opioid
system-vasopressin-adrenal axis, characterized by a prevalent immunosuppressive activity, and a brain
cannabinoid-oxytocin-pineal axis, which exerts an immunostimulatory role. The latter is relevant mainly
for anticancer immunity. The opioid-adrenal functional axis is active in stress and depressive conditions,
while the cannabinoid-pineal axis has been proven to be involved in pleasure perception and spiritual
expansion of mind. The findings could explain the predisposition to severe systemic diseases played by
stress and depression, and on the other hand the protective action of pleasure and spirituality in the onset
of important pathologies. The clinical and therapeutic applications of these concepts may constitute a
landmark for future Medicine. |
format |
Artículo |
topic_facet |
CANNABINOIDES CANCER COVID-19 CITOQUINAS MELATONINA NEUROPROTECCION INMUNOLOGIA SISTEMA INMUNOLOGICO |
author |
Lissoni, Paolo Brivio, Fernando Fumagalli, Luca Rovelli, Franco Colciago, Massimo Messina, Giusy Monzon, Alejandra Pelizzoni, Francesco Lissoni, Arianna Porro, Giorgio Di Fede, Giuseppe Cardinali, Daniel Pedro |
author_facet |
Lissoni, Paolo Brivio, Fernando Fumagalli, Luca Rovelli, Franco Colciago, Massimo Messina, Giusy Monzon, Alejandra Pelizzoni, Francesco Lissoni, Arianna Porro, Giorgio Di Fede, Giuseppe Cardinali, Daniel Pedro |
author_sort |
Lissoni, Paolo |
title |
How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach |
title_short |
How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach |
title_full |
How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach |
title_fullStr |
How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach |
title_full_unstemmed |
How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach |
title_sort |
how to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach |
publisher |
Crimson |
publishDate |
2021 |
url |
https://repositorio.uca.edu.ar/handle/123456789/13679 |
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