High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection

High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection

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Abstract: The therapeutic potential of melatonin as an agent to counteract the consequences of COVID-19 infections is due to its wide-ranging effects as a powerful antioxidant, anti-inflammatory, and immunostimulant, as well as to a possible antiviral action. In view of the recently reported evidence on the occurrence of neurological sequels in COVID-19-infected patients, another putative application of melatonin emerges based on its neuroprotective properties. In this manuscript a brief discussion of melatonin activity in animal models of ischemic and hemorrhagic stroke and the allometric calculations of the possible human equivalent doses are made. Based on the safety of melatonin, and in order to maximize its therapeutic opportunity, doses of 100 - 300 mg p.o. or i.v. are proposed.

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Bibliographic Details
Main Author: Cardinali, Daniel Pedro
Format: Artículo biblioteca
Language:spa
Published: ST Bio-Life 2020
Subjects:MELATONINA, CORONAVIRUS, COVID-19, ACCIDENTE CEREBROVASCULAR, NEUROPROTECCION, NEUROLOGIA,
Online Access:https://repositorio.uca.edu.ar/handle/123456789/10355
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spelling oai:ucacris:123456789-103552020-07-14T04:21:12Z High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection Cardinali, Daniel Pedro MELATONINA CORONAVIRUS COVID-19 ACCIDENTE CEREBROVASCULAR NEUROPROTECCION NEUROLOGIA Abstract: The therapeutic potential of melatonin as an agent to counteract the consequences of COVID-19 infections is due to its wide-ranging effects as a powerful antioxidant, anti-inflammatory, and immunostimulant, as well as to a possible antiviral action. In view of the recently reported evidence on the occurrence of neurological sequels in COVID-19-infected patients, another putative application of melatonin emerges based on its neuroprotective properties. In this manuscript a brief discussion of melatonin activity in animal models of ischemic and hemorrhagic stroke and the allometric calculations of the possible human equivalent doses are made. Based on the safety of melatonin, and in order to maximize its therapeutic opportunity, doses of 100 - 300 mg p.o. or i.v. are proposed. 2020-07-13T17:05:07Z 2020-07-13T17:05:07Z 2020 Artículo Cardinali, D.P. High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection [en línea]. Melatonin Research. 2020, 3(3). doi:10.32794/11250064 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/10355 2641-0281 https://repositorio.uca.edu.ar/handle/123456789/10355 10.32794/11250064 spa Acceso abierto http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf ST Bio-Life Melatonin Research. 2020, 3(3)
institution UCA
collection DSpace
country Argentina
countrycode AR
component Bibliográfico
access En linea
databasecode dig-uca
tag biblioteca
region America del Sur
libraryname Sistema de bibliotecas de la UCA
language spa
topic MELATONINA
CORONAVIRUS
COVID-19
ACCIDENTE CEREBROVASCULAR
NEUROPROTECCION
NEUROLOGIA
MELATONINA
CORONAVIRUS
COVID-19
ACCIDENTE CEREBROVASCULAR
NEUROPROTECCION
NEUROLOGIA
spellingShingle MELATONINA
CORONAVIRUS
COVID-19
ACCIDENTE CEREBROVASCULAR
NEUROPROTECCION
NEUROLOGIA
MELATONINA
CORONAVIRUS
COVID-19
ACCIDENTE CEREBROVASCULAR
NEUROPROTECCION
NEUROLOGIA
Cardinali, Daniel Pedro
High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection
description Abstract: The therapeutic potential of melatonin as an agent to counteract the consequences of COVID-19 infections is due to its wide-ranging effects as a powerful antioxidant, anti-inflammatory, and immunostimulant, as well as to a possible antiviral action. In view of the recently reported evidence on the occurrence of neurological sequels in COVID-19-infected patients, another putative application of melatonin emerges based on its neuroprotective properties. In this manuscript a brief discussion of melatonin activity in animal models of ischemic and hemorrhagic stroke and the allometric calculations of the possible human equivalent doses are made. Based on the safety of melatonin, and in order to maximize its therapeutic opportunity, doses of 100 - 300 mg p.o. or i.v. are proposed.
format Artículo
topic_facet MELATONINA
CORONAVIRUS
COVID-19
ACCIDENTE CEREBROVASCULAR
NEUROPROTECCION
NEUROLOGIA
author Cardinali, Daniel Pedro
author_facet Cardinali, Daniel Pedro
author_sort Cardinali, Daniel Pedro
title High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection
title_short High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection
title_full High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection
title_fullStr High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection
title_full_unstemmed High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection
title_sort high doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection
publisher ST Bio-Life
publishDate 2020
url https://repositorio.uca.edu.ar/handle/123456789/10355
work_keys_str_mv AT cardinalidanielpedro highdosesofmelatoninasapotentialtherapeutictoolfortheneurologicsequelsofcovid19infection
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