Elevated D-Dimer and acute pulmonary embolism in COVID-19 patients

Elevated D-Dimer and acute pulmonary embolism in COVID-19 patients

Abstract Introduction. It has been determined that patients with SARS-CoV-2 infection and severe pneumonia with elevated D-dimer values can develop acute pulmonary thromboembolism (APE) as a complication, being one of the causes related to mortality in this group of patients. Methods. A retrospective analysis of 12 patients diagnosed with SARS-CoV-2 infection with high clinical suspicion of APE confirmed by computed tomography pulmonary angiopgraphy (CTPA) was performed and the described findings are described. Results: 12 patients with diagnosis of severe pneumonia, elevated D-dimer 9.2 μg / ml (1.4 - ˃20 μg / mL) and confirmation of SARS-CoV-2 infection through real-time reverse transcription polymerasa chain reaction (RT-PCR). APEs were observed mainly in segmental arteries (75%) and main arteries (25%). Pneumonia with patched areas of bilateral ground glass opacities was observed in 100% of the sample as a typical finding of SARS-CoV-2 infection. Conclusion. SARS-CoV-2 infection is related to elevation of D-dimer and APE. The CTPA determines the diagnosis, severity and timely management (anticoagulation) of patients with APE. Therefore CTPA should be considered in all patients with elevated D-dimer or clinical worsening.

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Auteurs principaux: Santos-Poleo,Yoselin Dos, Pérez-Sánchez,Lorenzo, Ocanto,Abrahams, Oquillas-Izquierdo,Diana, Rodríguez-Recio,Francisco
Format: Digital revista
Langue:English
Publié: Research and Science S.L. 2020
Accès en ligne:https://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S2529-850X2020001200006
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spelling oai:scielo:S2529-850X20200012000062023-12-12Elevated D-Dimer and acute pulmonary embolism in COVID-19 patientsSantos-Poleo,Yoselin DosPérez-Sánchez,LorenzoOcanto,AbrahamsOquillas-Izquierdo,DianaRodríguez-Recio,Francisco COVID-19 embolism CT scan D-dimer radiology Abstract Introduction. It has been determined that patients with SARS-CoV-2 infection and severe pneumonia with elevated D-dimer values can develop acute pulmonary thromboembolism (APE) as a complication, being one of the causes related to mortality in this group of patients. Methods. A retrospective analysis of 12 patients diagnosed with SARS-CoV-2 infection with high clinical suspicion of APE confirmed by computed tomography pulmonary angiopgraphy (CTPA) was performed and the described findings are described. Results: 12 patients with diagnosis of severe pneumonia, elevated D-dimer 9.2 μg / ml (1.4 - ˃20 μg / mL) and confirmation of SARS-CoV-2 infection through real-time reverse transcription polymerasa chain reaction (RT-PCR). APEs were observed mainly in segmental arteries (75%) and main arteries (25%). Pneumonia with patched areas of bilateral ground glass opacities was observed in 100% of the sample as a typical finding of SARS-CoV-2 infection. Conclusion. SARS-CoV-2 infection is related to elevation of D-dimer and APE. The CTPA determines the diagnosis, severity and timely management (anticoagulation) of patients with APE. Therefore CTPA should be considered in all patients with elevated D-dimer or clinical worsening.Research and Science S.L.Journal of Negative and No Positive Results v.5 n.12 20202020-01-01journal articletext/htmlhttps://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S2529-850X2020001200006en
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country España
countrycode ES
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databasecode rev-scielo-es
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region Europa del Sur
libraryname SciELO
language English
format Digital
author Santos-Poleo,Yoselin Dos
Pérez-Sánchez,Lorenzo
Ocanto,Abrahams
Oquillas-Izquierdo,Diana
Rodríguez-Recio,Francisco
spellingShingle Santos-Poleo,Yoselin Dos
Pérez-Sánchez,Lorenzo
Ocanto,Abrahams
Oquillas-Izquierdo,Diana
Rodríguez-Recio,Francisco
Elevated D-Dimer and acute pulmonary embolism in COVID-19 patients
author_facet Santos-Poleo,Yoselin Dos
Pérez-Sánchez,Lorenzo
Ocanto,Abrahams
Oquillas-Izquierdo,Diana
Rodríguez-Recio,Francisco
author_sort Santos-Poleo,Yoselin Dos
title Elevated D-Dimer and acute pulmonary embolism in COVID-19 patients
title_short Elevated D-Dimer and acute pulmonary embolism in COVID-19 patients
title_full Elevated D-Dimer and acute pulmonary embolism in COVID-19 patients
title_fullStr Elevated D-Dimer and acute pulmonary embolism in COVID-19 patients
title_full_unstemmed Elevated D-Dimer and acute pulmonary embolism in COVID-19 patients
title_sort elevated d-dimer and acute pulmonary embolism in covid-19 patients
description Abstract Introduction. It has been determined that patients with SARS-CoV-2 infection and severe pneumonia with elevated D-dimer values can develop acute pulmonary thromboembolism (APE) as a complication, being one of the causes related to mortality in this group of patients. Methods. A retrospective analysis of 12 patients diagnosed with SARS-CoV-2 infection with high clinical suspicion of APE confirmed by computed tomography pulmonary angiopgraphy (CTPA) was performed and the described findings are described. Results: 12 patients with diagnosis of severe pneumonia, elevated D-dimer 9.2 μg / ml (1.4 - ˃20 μg / mL) and confirmation of SARS-CoV-2 infection through real-time reverse transcription polymerasa chain reaction (RT-PCR). APEs were observed mainly in segmental arteries (75%) and main arteries (25%). Pneumonia with patched areas of bilateral ground glass opacities was observed in 100% of the sample as a typical finding of SARS-CoV-2 infection. Conclusion. SARS-CoV-2 infection is related to elevation of D-dimer and APE. The CTPA determines the diagnosis, severity and timely management (anticoagulation) of patients with APE. Therefore CTPA should be considered in all patients with elevated D-dimer or clinical worsening.
publisher Research and Science S.L.
publishDate 2020
url https://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S2529-850X2020001200006
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AT rodriguezreciofrancisco elevatedddimerandacutepulmonaryembolismincovid19patients
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