Treatment options in hypoparathyroidism
ABSTRACT Hypoparathyroidism remains the single endocrine deficiency disease that is not habitually treated with the missing hormone. In this article, we aim to provide a review of the conventional approach and the novel therapies as well as an overview of the perspectives on the treatment of this rare condition. We conducted a literature review on the conventional therapy using vitamin D analogs and calcium salts, indications for thiazide diuretics and phosphorus binders, PTH analogs history and usage, and the drugs that are currently being tested in clinical trials. Conventional treatment involves calcium salts and vitamin D analogs. Thiazide diuretics can be used to reduce hypercalciuria in some cases. A low-phosphate diet is recommended, and phosphate binders are rarely needed. During pregnancy, a careful approach is necessary. The use of PTH analogs is a new approach despite the limitation of high cost. Studies have included modified PTH molecules, calcilytics, microencapsulation of human parathyroid cells, and allotransplantation.
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Sociedade Brasileira de Endocrinologia e Metabologia
2022
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oai:scielo:S2359-399720220005006512022-11-30Treatment options in hypoparathyroidismSakane,Eliane NaomiVieira,Maria Carolina CamargoVieira,Gabriela Mazzarolo MarcondesMaeda,Sergio Setsuo Hypoparathyroidism treatment PTH analogs vitamin D perspectives ABSTRACT Hypoparathyroidism remains the single endocrine deficiency disease that is not habitually treated with the missing hormone. In this article, we aim to provide a review of the conventional approach and the novel therapies as well as an overview of the perspectives on the treatment of this rare condition. We conducted a literature review on the conventional therapy using vitamin D analogs and calcium salts, indications for thiazide diuretics and phosphorus binders, PTH analogs history and usage, and the drugs that are currently being tested in clinical trials. Conventional treatment involves calcium salts and vitamin D analogs. Thiazide diuretics can be used to reduce hypercalciuria in some cases. A low-phosphate diet is recommended, and phosphate binders are rarely needed. During pregnancy, a careful approach is necessary. The use of PTH analogs is a new approach despite the limitation of high cost. Studies have included modified PTH molecules, calcilytics, microencapsulation of human parathyroid cells, and allotransplantation.info:eu-repo/semantics/openAccessSociedade Brasileira de Endocrinologia e MetabologiaArchives of Endocrinology and Metabolism v.66 n.5 20222022-10-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972022000500651en10.20945/2359-3997000000554 |
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| countrycode |
BR |
| component |
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revista |
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America del Sur |
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| language |
English |
| format |
Digital |
| author |
Sakane,Eliane Naomi Vieira,Maria Carolina Camargo Vieira,Gabriela Mazzarolo Marcondes Maeda,Sergio Setsuo |
| spellingShingle |
Sakane,Eliane Naomi Vieira,Maria Carolina Camargo Vieira,Gabriela Mazzarolo Marcondes Maeda,Sergio Setsuo Treatment options in hypoparathyroidism |
| author_facet |
Sakane,Eliane Naomi Vieira,Maria Carolina Camargo Vieira,Gabriela Mazzarolo Marcondes Maeda,Sergio Setsuo |
| author_sort |
Sakane,Eliane Naomi |
| title |
Treatment options in hypoparathyroidism |
| title_short |
Treatment options in hypoparathyroidism |
| title_full |
Treatment options in hypoparathyroidism |
| title_fullStr |
Treatment options in hypoparathyroidism |
| title_full_unstemmed |
Treatment options in hypoparathyroidism |
| title_sort |
treatment options in hypoparathyroidism |
| description |
ABSTRACT Hypoparathyroidism remains the single endocrine deficiency disease that is not habitually treated with the missing hormone. In this article, we aim to provide a review of the conventional approach and the novel therapies as well as an overview of the perspectives on the treatment of this rare condition. We conducted a literature review on the conventional therapy using vitamin D analogs and calcium salts, indications for thiazide diuretics and phosphorus binders, PTH analogs history and usage, and the drugs that are currently being tested in clinical trials. Conventional treatment involves calcium salts and vitamin D analogs. Thiazide diuretics can be used to reduce hypercalciuria in some cases. A low-phosphate diet is recommended, and phosphate binders are rarely needed. During pregnancy, a careful approach is necessary. The use of PTH analogs is a new approach despite the limitation of high cost. Studies have included modified PTH molecules, calcilytics, microencapsulation of human parathyroid cells, and allotransplantation. |
| publisher |
Sociedade Brasileira de Endocrinologia e Metabologia |
| publishDate |
2022 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972022000500651 |
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