Is there a relationship between preoperative cytological diagnosis and evolution in patients with differentiated thyroid carcinoma? A retrospective study
ABSTRACT Objective: Cytological analysis and Bethesda classification of thyroid nodules is the standard method of diagnosing differentiated thyroid carcinoma (DTC). However, even for nodules with a non-malignant cytological diagnosis, there is a not insignificant risk of cancer. There are doubts whether this lack of certainty would influence patient prognosis. Our aim was to compare patients with DTC, classified according to the preoperative cytological diagnosis, regarding their evolution. Subjects and methods: A retrospective study was carried out with 108 DTC patients submitted to total thyroidectomy (TT) between 2009 and 2015, divided into three groups according to preoperative cytological diagnosis (Bethesda classification): classes I/II, III/IV, and V/VI. Groups were compared for evolution considering response to treatment at last evaluation as well as time disease free. Statistical analysis used ANOVA, chi squared, and Kaplan-Meier curves with p<0.05 considered significant. Results: Groups differed for time between nodule puncture and TT [in months; V/VI (2.35 ± 2.48) < III/IV (7.32 ± 6.34) < I/II (13.36 ± 8.9); p < 0.0001]. There was no significant difference between groups for evolution at final evaluation (disease free status; classes I/II: 71.4%; classes III/IV: 60%; classes V/VI: 66.6%; p = 0.7433), as well as time disease free (in months; classes I/II: 34.57 ± 25.82; classes III/IV: 38.04 ± 26.66; classes V/VI: 30.84 ± 26.34; p = 0.3841). Conclusions: DTC patients classified according to preoperative cytological diagnosis did not differ for evolution. Although patients with non-malignant cytological diagnoses were submitted to TT later, this did not affect the evolution of the cases.
Main Authors: | Colenci,Renato, Minicucci,Marcos Ferreira, Soares,Carlos Segundo Paiva, Oliveira,Cristiano Claudino de, Marques,Mariângela Esther de Alencar, Tagliarini,José Vicente, Mazeto,Gláucia Maria Ferreira da Silva |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Sociedade Brasileira de Endocrinologia e Metabologia
2022
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972022000200237 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Thyroglobulin/thyrotropin ratio for predicting long-term response in differentiated thyroid carcinoma: a retrospective study
by: Marchi Junior,Adriano Francisco De, et al.
Published: (2021) -
Usefulness of preoperative serum calcitonin in patients with nodular thyroid disease without suspicious history or cytology for medullary thyroid carcinoma
by: Rosário,Pedro Weslley, et al.
Published: (2013) -
Use of strain ultrasound elastography versus fine-needle aspiration cytology for the differential diagnosis of thyroid nodules: a retrospective analysis
by: Yang,Xianghua, et al.
Published: (2020) -
Preoperative vitamin D level as a post-total thyroidectomy hypocalcemia predictor: a prospective study
by: Soares,Carlos Segundo Paiva, et al.
Published: (2021) -
Preoperative assessment of thyroid nodules: role of ultrasonography and fine needle aspiration biopsy followed by cytology
by: Camargo,Rosalinda YA, et al.
Published: (2007)