Idiopathic Lipoid Pneumonia: An incidental finding in autopsy specimen
ABSTRACT Lipoid pneumonia is a rare form of pneumonia which was initially described to be caused by inhalation or aspiration of fatty substances. Certain autopsy studies have reported the incidence to be 1.0-2.5%. Based on the mode of lipid acquisition, it has been classified into endogenous, exogenous or idiopathic types. Almost 50% of the patients with lipoid pneumonia are asymptomatic, and may be discovered by chance during routine chest imaging. In symptomatic patients, the symptoms are non- specific. However, it can produce inflammatory pneumonitis that can progress to irreversible pulmonary fibrosis as seen in our case. We present a case of a 53-year-old deceased male. A piece of one of his lungs was received after autopsy, which appeared normal grossly. There was no history of any illness before death. Microscopy revealed interstitial fibrosis with collection of foamy macrophages in alveolar spaces and cholesterol crystals surrounded by inflammatory reaction including occasional giant cells. The clinical picture and radiologic changes in cases of lipoid pneumonia can mimic bacterial pneumonia and tuberculosis. The occupational history is of extreme importance and should always be investigated.
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Hospital Universitário da Universidade de São Paulo
2020
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oai:scielo:S2236-196020200001003032020-10-19Idiopathic Lipoid Pneumonia: An incidental finding in autopsy specimenRana,DeepshikhaKaushik,NidhiSadhu,ShreyaKalra,RajnishSen,Rajeev Pneumonia macrophages Lipids ABSTRACT Lipoid pneumonia is a rare form of pneumonia which was initially described to be caused by inhalation or aspiration of fatty substances. Certain autopsy studies have reported the incidence to be 1.0-2.5%. Based on the mode of lipid acquisition, it has been classified into endogenous, exogenous or idiopathic types. Almost 50% of the patients with lipoid pneumonia are asymptomatic, and may be discovered by chance during routine chest imaging. In symptomatic patients, the symptoms are non- specific. However, it can produce inflammatory pneumonitis that can progress to irreversible pulmonary fibrosis as seen in our case. We present a case of a 53-year-old deceased male. A piece of one of his lungs was received after autopsy, which appeared normal grossly. There was no history of any illness before death. Microscopy revealed interstitial fibrosis with collection of foamy macrophages in alveolar spaces and cholesterol crystals surrounded by inflammatory reaction including occasional giant cells. The clinical picture and radiologic changes in cases of lipoid pneumonia can mimic bacterial pneumonia and tuberculosis. The occupational history is of extreme importance and should always be investigated.info:eu-repo/semantics/openAccessHospital Universitário da Universidade de São PauloAutopsy and Case Reports v.10 n.1 20202020-01-01info:eu-repo/semantics/reporttext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2236-19602020000100303en10.4322/acr.2020.143 |
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Rana,Deepshikha Kaushik,Nidhi Sadhu,Shreya Kalra,Rajnish Sen,Rajeev |
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Rana,Deepshikha Kaushik,Nidhi Sadhu,Shreya Kalra,Rajnish Sen,Rajeev Idiopathic Lipoid Pneumonia: An incidental finding in autopsy specimen |
author_facet |
Rana,Deepshikha Kaushik,Nidhi Sadhu,Shreya Kalra,Rajnish Sen,Rajeev |
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Rana,Deepshikha |
title |
Idiopathic Lipoid Pneumonia: An incidental finding in autopsy specimen |
title_short |
Idiopathic Lipoid Pneumonia: An incidental finding in autopsy specimen |
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Idiopathic Lipoid Pneumonia: An incidental finding in autopsy specimen |
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Idiopathic Lipoid Pneumonia: An incidental finding in autopsy specimen |
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Idiopathic Lipoid Pneumonia: An incidental finding in autopsy specimen |
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idiopathic lipoid pneumonia: an incidental finding in autopsy specimen |
description |
ABSTRACT Lipoid pneumonia is a rare form of pneumonia which was initially described to be caused by inhalation or aspiration of fatty substances. Certain autopsy studies have reported the incidence to be 1.0-2.5%. Based on the mode of lipid acquisition, it has been classified into endogenous, exogenous or idiopathic types. Almost 50% of the patients with lipoid pneumonia are asymptomatic, and may be discovered by chance during routine chest imaging. In symptomatic patients, the symptoms are non- specific. However, it can produce inflammatory pneumonitis that can progress to irreversible pulmonary fibrosis as seen in our case. We present a case of a 53-year-old deceased male. A piece of one of his lungs was received after autopsy, which appeared normal grossly. There was no history of any illness before death. Microscopy revealed interstitial fibrosis with collection of foamy macrophages in alveolar spaces and cholesterol crystals surrounded by inflammatory reaction including occasional giant cells. The clinical picture and radiologic changes in cases of lipoid pneumonia can mimic bacterial pneumonia and tuberculosis. The occupational history is of extreme importance and should always be investigated. |
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Hospital Universitário da Universidade de São Paulo |
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2020 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2236-19602020000100303 |
work_keys_str_mv |
AT ranadeepshikha idiopathiclipoidpneumoniaanincidentalfindinginautopsyspecimen AT kaushiknidhi idiopathiclipoidpneumoniaanincidentalfindinginautopsyspecimen AT sadhushreya idiopathiclipoidpneumoniaanincidentalfindinginautopsyspecimen AT kalrarajnish idiopathiclipoidpneumoniaanincidentalfindinginautopsyspecimen AT senrajeev idiopathiclipoidpneumoniaanincidentalfindinginautopsyspecimen |
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