Mini-Mental State Examination and proton spectroscopy of the posterior cingulate in Alzheimer disease
Abstract To compare metabolite ratios in the posterior cingulate with the Mini-Mental State Examination (MMSE) test scores in patients with mild or moderate Alzheimer disease and in controls. Methods: We evaluated 29 patients with mild or moderate Alzheimer disease and 15 controls by proton spectroscopy with the voxel located in the posterior cingulate. The MMSE was applied to all patients and controls. The metabolic ratios: N-acetyl-aspartate/creatine (Naa/Cr), mio-inositol/creatine (mI/Cr) and mio-inositol/N-acetyl-aspartate (mI/Naa) were obtained and then post-processed using the MRUI software (magnetic resonance user interface). Results: Correlation between Naa/Cr and mI/Naa ratios in the posterior cingulate with the MMSE was observed, and a positive correlation with Naa/Cr and negative correlation with mI/Naa were seen. The mI/r ratio presented no correlation with MMSE scores. Conclusion: The positive correlation with Naa/Cr, and negative correlation with mI/Naa may corroborate that neuronal density/viability is associated to a higher MMSE score.
Main Authors: | , , , , |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
2007
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642007000300248 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
oai:scielo:S1980-57642007000300248 |
---|---|
record_format |
ojs |
spelling |
oai:scielo:S1980-576420070003002482016-09-30Mini-Mental State Examination and proton spectroscopy of the posterior cingulate in Alzheimer diseaseLee,Hae WonCaramelli,PauloOtaduy,Maria Concepcion GarciaNitrini,RicardoLeite,Claudia da Costa proton spectroscopy posterior cingulate single voxel MMSE test Alzheimer disease. Abstract To compare metabolite ratios in the posterior cingulate with the Mini-Mental State Examination (MMSE) test scores in patients with mild or moderate Alzheimer disease and in controls. Methods: We evaluated 29 patients with mild or moderate Alzheimer disease and 15 controls by proton spectroscopy with the voxel located in the posterior cingulate. The MMSE was applied to all patients and controls. The metabolic ratios: N-acetyl-aspartate/creatine (Naa/Cr), mio-inositol/creatine (mI/Cr) and mio-inositol/N-acetyl-aspartate (mI/Naa) were obtained and then post-processed using the MRUI software (magnetic resonance user interface). Results: Correlation between Naa/Cr and mI/Naa ratios in the posterior cingulate with the MMSE was observed, and a positive correlation with Naa/Cr and negative correlation with mI/Naa were seen. The mI/r ratio presented no correlation with MMSE scores. Conclusion: The positive correlation with Naa/Cr, and negative correlation with mI/Naa may corroborate that neuronal density/viability is associated to a higher MMSE score.info:eu-repo/semantics/openAccessAcademia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e EnvelhecimentoDementia & Neuropsychologia v.1 n.3 20072007-09-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642007000300248en10.1590/S1980-57642008DN10300005 |
institution |
SCIELO |
collection |
OJS |
country |
Brasil |
countrycode |
BR |
component |
Revista |
access |
En linea |
databasecode |
rev-scielo-br |
tag |
revista |
region |
America del Sur |
libraryname |
SciELO |
language |
English |
format |
Digital |
author |
Lee,Hae Won Caramelli,Paulo Otaduy,Maria Concepcion Garcia Nitrini,Ricardo Leite,Claudia da Costa |
spellingShingle |
Lee,Hae Won Caramelli,Paulo Otaduy,Maria Concepcion Garcia Nitrini,Ricardo Leite,Claudia da Costa Mini-Mental State Examination and proton spectroscopy of the posterior cingulate in Alzheimer disease |
author_facet |
Lee,Hae Won Caramelli,Paulo Otaduy,Maria Concepcion Garcia Nitrini,Ricardo Leite,Claudia da Costa |
author_sort |
Lee,Hae Won |
title |
Mini-Mental State Examination and proton spectroscopy of the posterior cingulate in Alzheimer disease |
title_short |
Mini-Mental State Examination and proton spectroscopy of the posterior cingulate in Alzheimer disease |
title_full |
Mini-Mental State Examination and proton spectroscopy of the posterior cingulate in Alzheimer disease |
title_fullStr |
Mini-Mental State Examination and proton spectroscopy of the posterior cingulate in Alzheimer disease |
title_full_unstemmed |
Mini-Mental State Examination and proton spectroscopy of the posterior cingulate in Alzheimer disease |
title_sort |
mini-mental state examination and proton spectroscopy of the posterior cingulate in alzheimer disease |
description |
Abstract To compare metabolite ratios in the posterior cingulate with the Mini-Mental State Examination (MMSE) test scores in patients with mild or moderate Alzheimer disease and in controls. Methods: We evaluated 29 patients with mild or moderate Alzheimer disease and 15 controls by proton spectroscopy with the voxel located in the posterior cingulate. The MMSE was applied to all patients and controls. The metabolic ratios: N-acetyl-aspartate/creatine (Naa/Cr), mio-inositol/creatine (mI/Cr) and mio-inositol/N-acetyl-aspartate (mI/Naa) were obtained and then post-processed using the MRUI software (magnetic resonance user interface). Results: Correlation between Naa/Cr and mI/Naa ratios in the posterior cingulate with the MMSE was observed, and a positive correlation with Naa/Cr and negative correlation with mI/Naa were seen. The mI/r ratio presented no correlation with MMSE scores. Conclusion: The positive correlation with Naa/Cr, and negative correlation with mI/Naa may corroborate that neuronal density/viability is associated to a higher MMSE score. |
publisher |
Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento |
publishDate |
2007 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642007000300248 |
work_keys_str_mv |
AT leehaewon minimentalstateexaminationandprotonspectroscopyoftheposteriorcingulateinalzheimerdisease AT caramellipaulo minimentalstateexaminationandprotonspectroscopyoftheposteriorcingulateinalzheimerdisease AT otaduymariaconcepciongarcia minimentalstateexaminationandprotonspectroscopyoftheposteriorcingulateinalzheimerdisease AT nitriniricardo minimentalstateexaminationandprotonspectroscopyoftheposteriorcingulateinalzheimerdisease AT leiteclaudiadacosta minimentalstateexaminationandprotonspectroscopyoftheposteriorcingulateinalzheimerdisease |
_version_ |
1756434409490219008 |