Is There a Difference between the Preoperative and Postoperative Serum Levels of Interleukin-6 and Tumor Necrosis Factor-α in Children Submitted to Adenotonsillectomy?

Is There a Difference between the Preoperative and Postoperative Serum Levels of Interleukin-6 and Tumor Necrosis Factor-α in Children Submitted to Adenotonsillectomy?

Abstract Introduction Palatine and pharyngeal tonsils are the first line of defense against pathogens. Clinically, two alterations may require surgical removal of the tonsils: hypertrophy and recurrent tonsillitis. The two conditions probably result from a dysfunction of the immune system. Objective To evaluate possible differences in the plasma levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-10 (IL-10) in patients submitted to adenotonsillectomy. Methods Prospective, longitudinal study with 25 children undergoing adenotonsillectomy separated into 3 different groups: recurrent tonsillitis (RT), composed of 7 patients; recurrent hypertrophy tonsillitis (RTTH), with 8 patients; and the tonsillar hypertrophy (TH) group, with 10 patients. Ten healthy control children (SD) were also included in the study. Peripheral blood was collected, and plasma was separated to measure the levels of TNF-α, IL-6, and IL-10. The Mann-Whitney test was used for statistical analysis. Results The plasma level of IL-6 was higher in the RT (p= 0.0394) and TH (p= 0.0009) groups, compared with the control group. The TH group also had higher levels of IL-6 than the RT group (p= 0.039). The IL-6/IL-10 ratio was higher in the RT (p= 0.029) and TH (p= 0.0005) groups compared with the control group. Between the RT and RTTH groups, the IL-6/IL-10 ratio was higher in the RT group, with a statistically significant difference (p= 0.0091). Conclusion Patients with a history of chronic tonsillitis had higher levels of IL-6, compared with the control group.

Saved in:
Bibliographic Details
Main Authors: de Souza,Jose Neto Ribeiro, de Castro,Fernanda de Oliveira Feitosa, de Souza,Camila Lemes, El Cheikh,Mikhael Romanholo, Ramos,Hugo Valter Lisboa, da Fonseca,Simone Gonçalves, Costa,Claudiney Candido
Format: Digital revista
Language:English
Published: Fundação Otorrinolaringologia 2022
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1809-48642022000200004
Tags: Add Tag
No Tags, Be the first to tag this record!
id oai:scielo:S1809-48642022000200004
record_format ojs
spelling oai:scielo:S1809-486420220002000042022-06-14Is There a Difference between the Preoperative and Postoperative Serum Levels of Interleukin-6 and Tumor Necrosis Factor-α in Children Submitted to Adenotonsillectomy?de Souza,Jose Neto Ribeirode Castro,Fernanda de Oliveira Feitosade Souza,Camila LemesEl Cheikh,Mikhael RomanholoRamos,Hugo Valter Lisboada Fonseca,Simone GonçalvesCosta,Claudiney Candido chronic tonsillitis tonsillar hypertrophy adenotonsillectomy cytokines Abstract Introduction Palatine and pharyngeal tonsils are the first line of defense against pathogens. Clinically, two alterations may require surgical removal of the tonsils: hypertrophy and recurrent tonsillitis. The two conditions probably result from a dysfunction of the immune system. Objective To evaluate possible differences in the plasma levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-10 (IL-10) in patients submitted to adenotonsillectomy. Methods Prospective, longitudinal study with 25 children undergoing adenotonsillectomy separated into 3 different groups: recurrent tonsillitis (RT), composed of 7 patients; recurrent hypertrophy tonsillitis (RTTH), with 8 patients; and the tonsillar hypertrophy (TH) group, with 10 patients. Ten healthy control children (SD) were also included in the study. Peripheral blood was collected, and plasma was separated to measure the levels of TNF-α, IL-6, and IL-10. The Mann-Whitney test was used for statistical analysis. Results The plasma level of IL-6 was higher in the RT (p= 0.0394) and TH (p= 0.0009) groups, compared with the control group. The TH group also had higher levels of IL-6 than the RT group (p= 0.039). The IL-6/IL-10 ratio was higher in the RT (p= 0.029) and TH (p= 0.0005) groups compared with the control group. Between the RT and RTTH groups, the IL-6/IL-10 ratio was higher in the RT group, with a statistically significant difference (p= 0.0091). Conclusion Patients with a history of chronic tonsillitis had higher levels of IL-6, compared with the control group.info:eu-repo/semantics/openAccessFundação OtorrinolaringologiaInternational Archives of Otorhinolaryngology v.26 n.2 20222022-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1809-48642022000200004en10.1055/s-0041-1730301
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author de Souza,Jose Neto Ribeiro
de Castro,Fernanda de Oliveira Feitosa
de Souza,Camila Lemes
El Cheikh,Mikhael Romanholo
Ramos,Hugo Valter Lisboa
da Fonseca,Simone Gonçalves
Costa,Claudiney Candido
spellingShingle de Souza,Jose Neto Ribeiro
de Castro,Fernanda de Oliveira Feitosa
de Souza,Camila Lemes
El Cheikh,Mikhael Romanholo
Ramos,Hugo Valter Lisboa
da Fonseca,Simone Gonçalves
Costa,Claudiney Candido
Is There a Difference between the Preoperative and Postoperative Serum Levels of Interleukin-6 and Tumor Necrosis Factor-α in Children Submitted to Adenotonsillectomy?
author_facet de Souza,Jose Neto Ribeiro
de Castro,Fernanda de Oliveira Feitosa
de Souza,Camila Lemes
El Cheikh,Mikhael Romanholo
Ramos,Hugo Valter Lisboa
da Fonseca,Simone Gonçalves
Costa,Claudiney Candido
author_sort de Souza,Jose Neto Ribeiro
title Is There a Difference between the Preoperative and Postoperative Serum Levels of Interleukin-6 and Tumor Necrosis Factor-α in Children Submitted to Adenotonsillectomy?
title_short Is There a Difference between the Preoperative and Postoperative Serum Levels of Interleukin-6 and Tumor Necrosis Factor-α in Children Submitted to Adenotonsillectomy?
title_full Is There a Difference between the Preoperative and Postoperative Serum Levels of Interleukin-6 and Tumor Necrosis Factor-α in Children Submitted to Adenotonsillectomy?
title_fullStr Is There a Difference between the Preoperative and Postoperative Serum Levels of Interleukin-6 and Tumor Necrosis Factor-α in Children Submitted to Adenotonsillectomy?
title_full_unstemmed Is There a Difference between the Preoperative and Postoperative Serum Levels of Interleukin-6 and Tumor Necrosis Factor-α in Children Submitted to Adenotonsillectomy?
title_sort is there a difference between the preoperative and postoperative serum levels of interleukin-6 and tumor necrosis factor-α in children submitted to adenotonsillectomy?
description Abstract Introduction Palatine and pharyngeal tonsils are the first line of defense against pathogens. Clinically, two alterations may require surgical removal of the tonsils: hypertrophy and recurrent tonsillitis. The two conditions probably result from a dysfunction of the immune system. Objective To evaluate possible differences in the plasma levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-10 (IL-10) in patients submitted to adenotonsillectomy. Methods Prospective, longitudinal study with 25 children undergoing adenotonsillectomy separated into 3 different groups: recurrent tonsillitis (RT), composed of 7 patients; recurrent hypertrophy tonsillitis (RTTH), with 8 patients; and the tonsillar hypertrophy (TH) group, with 10 patients. Ten healthy control children (SD) were also included in the study. Peripheral blood was collected, and plasma was separated to measure the levels of TNF-α, IL-6, and IL-10. The Mann-Whitney test was used for statistical analysis. Results The plasma level of IL-6 was higher in the RT (p= 0.0394) and TH (p= 0.0009) groups, compared with the control group. The TH group also had higher levels of IL-6 than the RT group (p= 0.039). The IL-6/IL-10 ratio was higher in the RT (p= 0.029) and TH (p= 0.0005) groups compared with the control group. Between the RT and RTTH groups, the IL-6/IL-10 ratio was higher in the RT group, with a statistically significant difference (p= 0.0091). Conclusion Patients with a history of chronic tonsillitis had higher levels of IL-6, compared with the control group.
publisher Fundação Otorrinolaringologia
publishDate 2022
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1809-48642022000200004
work_keys_str_mv AT desouzajosenetoribeiro isthereadifferencebetweenthepreoperativeandpostoperativeserumlevelsofinterleukin6andtumornecrosisfactorainchildrensubmittedtoadenotonsillectomy
AT decastrofernandadeoliveirafeitosa isthereadifferencebetweenthepreoperativeandpostoperativeserumlevelsofinterleukin6andtumornecrosisfactorainchildrensubmittedtoadenotonsillectomy
AT desouzacamilalemes isthereadifferencebetweenthepreoperativeandpostoperativeserumlevelsofinterleukin6andtumornecrosisfactorainchildrensubmittedtoadenotonsillectomy
AT elcheikhmikhaelromanholo isthereadifferencebetweenthepreoperativeandpostoperativeserumlevelsofinterleukin6andtumornecrosisfactorainchildrensubmittedtoadenotonsillectomy
AT ramoshugovalterlisboa isthereadifferencebetweenthepreoperativeandpostoperativeserumlevelsofinterleukin6andtumornecrosisfactorainchildrensubmittedtoadenotonsillectomy
AT dafonsecasimonegoncalves isthereadifferencebetweenthepreoperativeandpostoperativeserumlevelsofinterleukin6andtumornecrosisfactorainchildrensubmittedtoadenotonsillectomy
AT costaclaudineycandido isthereadifferencebetweenthepreoperativeandpostoperativeserumlevelsofinterleukin6andtumornecrosisfactorainchildrensubmittedtoadenotonsillectomy
_version_ 1756433701306105856

Similar Items