2021 Brazilian Thoracic Association recommendations for the management of severe asthma

ABSTRACT Advances in the understanding that severe asthma is a complex and heterogeneous disease and in the knowledge of the pathophysiology of asthma, with the identification of different phenotypes and endotypes, have allowed new approaches for the diagnosis and characterization of the disease and have resulted in relevant changes in pharmacological management. In this context, the definition of severe asthma has been established, being differentiated from difficult-to-control asthma. These recommendations address this topic and review advances in phenotyping, use of biomarkers, and new treatments for severe asthma. Emphasis is given to topics regarding personalized management of the patient and selection of biologicals, as well as the importance of evaluating the response to treatment. These recommendations apply to adults and children with severe asthma and are targeted at physicians involved in asthma treatment. A panel of 17 Brazilian pulmonologists was invited to review recent evidence on the diagnosis and management of severe asthma, adapting it to the Brazilian reality. Each of the experts was responsible for reviewing a topic or question relevant to the topic. In a second phase, four experts discussed and structured the texts produced, and, in the last phase, all experts reviewed and approved the present manuscript and its recommendations.

Bibliographic Details

Main Authors:	Carvalho-Pinto,Regina Maria de, Cançado,José Eduardo Delfini, Pizzichini,Marcia Margaret Menezes, Fiterman,Jussara, Rubin,Adalberto Sperb, Cerci Neto,Alcindo, Cruz,Álvaro Augusto, Fernandes,Ana Luisa Godoy, Araujo,Ana Maria Silva, Blanco,Daniela Cavalet, Cordeiro Junior,Gediel, Caetano,Lilian Serrasqueiro Ballini, Rabahi,Marcelo Fouad, Menezes,Marcelo Bezerra de, Oliveira,Maria Alenita de, Lima,Marina Andrade, Pitrez,Paulo Márcio
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Pneumologia e Tisiologia 2021
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132021000600400
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