pH and salivary sodium bicarbonate during the administration protocol for methotrexate in children with leukemia

pH and salivary sodium bicarbonate during the administration protocol for methotrexate in children with leukemia

Objective: To analyze the behavior of pH and sodium bicarbonate (NAHCO3) in the saliva of patients with leukemia during the administration protocol for Methotrexate (Mtx). Materials and Methods: A controlled clinical essay was carried out on 23 patients between 4 and 18 years of age with high-risk Acute Lymphoblastic Leukemia. Sampling was carried out at To: basal condition; T1: 12 hours after intravenous administration of sodium bicarbonate, before administering Mtx and T2: 3 hours after administering Mtx, the time of maximum concentration. Chiron-Diagnostic 378® equipment was used to determine pH and sodium bicarbonate. The data was interpreted using Analysis of Variance at the 5% significance level. Results: The highest values of sodium bicarbonate were observed at T2, with salivary pH levels remaining within neutrality ranges, diminishing slightly in T1. Conclusion. In this study, the dose of sodium bicarbonate considered in the administration protocol of 3 g /m² Mtx, kept sodium bicarbonate levels in saliva at normal levels and pH neutral.

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Main Authors: Rojas de Morales,Thais, Navas,Rita, Viera,Ninoska, Álvarez,Carmen Julia, Chaparro,Neira, Griman,Dariana
Format: Digital revista
Language:English
Published: Sociedad Española de Medicina Oral 2007
Online Access:http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1698-69462007000600005
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spelling oai:scielo:S1698-694620070006000052008-07-18pH and salivary sodium bicarbonate during the administration protocol for methotrexate in children with leukemiaRojas de Morales,ThaisNavas,RitaViera,NinoskaÁlvarez,Carmen JuliaChaparro,NeiraGriman,Dariana Salivary pH salivary sodium bicarbonate methotrexate leukemia Objective: To analyze the behavior of pH and sodium bicarbonate (NAHCO3) in the saliva of patients with leukemia during the administration protocol for Methotrexate (Mtx). Materials and Methods: A controlled clinical essay was carried out on 23 patients between 4 and 18 years of age with high-risk Acute Lymphoblastic Leukemia. Sampling was carried out at To: basal condition; T1: 12 hours after intravenous administration of sodium bicarbonate, before administering Mtx and T2: 3 hours after administering Mtx, the time of maximum concentration. Chiron-Diagnostic 378® equipment was used to determine pH and sodium bicarbonate. The data was interpreted using Analysis of Variance at the 5% significance level. Results: The highest values of sodium bicarbonate were observed at T2, with salivary pH levels remaining within neutrality ranges, diminishing slightly in T1. Conclusion. In this study, the dose of sodium bicarbonate considered in the administration protocol of 3 g /m² Mtx, kept sodium bicarbonate levels in saliva at normal levels and pH neutral.Sociedad Española de Medicina OralMedicina Oral, Patología Oral y Cirugía Bucal (Internet) v.12 n.6 20072007-10-01journal articletext/htmlhttp://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1698-69462007000600005en
institution SCIELO
collection OJS
country España
countrycode ES
component Revista
access En linea
databasecode rev-scielo-es
tag revista
region Europa del Sur
libraryname SciELO
language English
format Digital
author Rojas de Morales,Thais
Navas,Rita
Viera,Ninoska
Álvarez,Carmen Julia
Chaparro,Neira
Griman,Dariana
spellingShingle Rojas de Morales,Thais
Navas,Rita
Viera,Ninoska
Álvarez,Carmen Julia
Chaparro,Neira
Griman,Dariana
pH and salivary sodium bicarbonate during the administration protocol for methotrexate in children with leukemia
author_facet Rojas de Morales,Thais
Navas,Rita
Viera,Ninoska
Álvarez,Carmen Julia
Chaparro,Neira
Griman,Dariana
author_sort Rojas de Morales,Thais
title pH and salivary sodium bicarbonate during the administration protocol for methotrexate in children with leukemia
title_short pH and salivary sodium bicarbonate during the administration protocol for methotrexate in children with leukemia
title_full pH and salivary sodium bicarbonate during the administration protocol for methotrexate in children with leukemia
title_fullStr pH and salivary sodium bicarbonate during the administration protocol for methotrexate in children with leukemia
title_full_unstemmed pH and salivary sodium bicarbonate during the administration protocol for methotrexate in children with leukemia
title_sort ph and salivary sodium bicarbonate during the administration protocol for methotrexate in children with leukemia
description Objective: To analyze the behavior of pH and sodium bicarbonate (NAHCO3) in the saliva of patients with leukemia during the administration protocol for Methotrexate (Mtx). Materials and Methods: A controlled clinical essay was carried out on 23 patients between 4 and 18 years of age with high-risk Acute Lymphoblastic Leukemia. Sampling was carried out at To: basal condition; T1: 12 hours after intravenous administration of sodium bicarbonate, before administering Mtx and T2: 3 hours after administering Mtx, the time of maximum concentration. Chiron-Diagnostic 378® equipment was used to determine pH and sodium bicarbonate. The data was interpreted using Analysis of Variance at the 5% significance level. Results: The highest values of sodium bicarbonate were observed at T2, with salivary pH levels remaining within neutrality ranges, diminishing slightly in T1. Conclusion. In this study, the dose of sodium bicarbonate considered in the administration protocol of 3 g /m² Mtx, kept sodium bicarbonate levels in saliva at normal levels and pH neutral.
publisher Sociedad Española de Medicina Oral
publishDate 2007
url http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1698-69462007000600005
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AT navasrita phandsalivarysodiumbicarbonateduringtheadministrationprotocolformethotrexateinchildrenwithleukemia
AT vieraninoska phandsalivarysodiumbicarbonateduringtheadministrationprotocolformethotrexateinchildrenwithleukemia
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