Degradation study of poly(lactic-L(+)-co-glycolic acid) in chloroform

Degradation study of poly(lactic-L(+)-co-glycolic acid) in chloroform

Polymer/solvent interaction has been of great interest in many fields, such as scaffold processing, polymer recycling and drug delivery system (DDS), among others. It has been reported that the effect of solvent on polymers could determine the final physical and chemical properties in specific applications. Thus, this article describes a degradation study of poly(lactic-L(+)-co-glycolic acid), or PLGA, in the presence of chloroform. The PLGA polymer was synthetized by ring opening polymerization (ROP). Five lactic/glycolic acid volumetric ratios (90/10, 80/20, 70/30, 60/40 and 50/50) were used to prepare PLGA. Copolymers were characterized using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) and static light scattering (SLS). Copolymer degradation was induced using chloroform as the solvent. FTIR was used to follow variations on the functional groups of copolymers during the PLGA degradation process. The study was conducted using the evidence provided from the modifications of OH wavelength bands (3000-3500 cm-1) obtained from FTIR. A viable reaction scheme to explain the degradation of the copolymer was developed based on the monomolecular constant reaction rates generated by the decomposition dynamic of OH groups.

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Main Authors: Rueda,C., Vallejo,I., Corea,M., Palacios,E. G., Chairez,I.
Format: Digital revista
Language:English
Published: Universidad Autónoma Metropolitana, División de Ciencias Básicas e Ingeniería 2015
Online Access:http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1665-27382015000300023
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spelling oai:scielo:S1665-273820150003000232016-06-27Degradation study of poly(lactic-L(+)-co-glycolic acid) in chloroformRueda,C.Vallejo,I.Corea,M.Palacios,E. G.Chairez,I. poly(lactic-L(+)-co-glycolic acid) kinetic study chloroform degradation biopolymers Polymer/solvent interaction has been of great interest in many fields, such as scaffold processing, polymer recycling and drug delivery system (DDS), among others. It has been reported that the effect of solvent on polymers could determine the final physical and chemical properties in specific applications. Thus, this article describes a degradation study of poly(lactic-L(+)-co-glycolic acid), or PLGA, in the presence of chloroform. The PLGA polymer was synthetized by ring opening polymerization (ROP). Five lactic/glycolic acid volumetric ratios (90/10, 80/20, 70/30, 60/40 and 50/50) were used to prepare PLGA. Copolymers were characterized using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) and static light scattering (SLS). Copolymer degradation was induced using chloroform as the solvent. FTIR was used to follow variations on the functional groups of copolymers during the PLGA degradation process. The study was conducted using the evidence provided from the modifications of OH wavelength bands (3000-3500 cm-1) obtained from FTIR. A viable reaction scheme to explain the degradation of the copolymer was developed based on the monomolecular constant reaction rates generated by the decomposition dynamic of OH groups.info:eu-repo/semantics/openAccessUniversidad Autónoma Metropolitana, División de Ciencias Básicas e IngenieríaRevista mexicana de ingeniería química v.14 n.3 20152015-12-01info:eu-repo/semantics/articletext/htmlhttp://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1665-27382015000300023en
institution SCIELO
collection OJS
country México
countrycode MX
component Revista
access En linea
databasecode rev-scielo-mx
tag revista
region America del Norte
libraryname SciELO
language English
format Digital
author Rueda,C.
Vallejo,I.
Corea,M.
Palacios,E. G.
Chairez,I.
spellingShingle Rueda,C.
Vallejo,I.
Corea,M.
Palacios,E. G.
Chairez,I.
Degradation study of poly(lactic-L(+)-co-glycolic acid) in chloroform
author_facet Rueda,C.
Vallejo,I.
Corea,M.
Palacios,E. G.
Chairez,I.
author_sort Rueda,C.
title Degradation study of poly(lactic-L(+)-co-glycolic acid) in chloroform
title_short Degradation study of poly(lactic-L(+)-co-glycolic acid) in chloroform
title_full Degradation study of poly(lactic-L(+)-co-glycolic acid) in chloroform
title_fullStr Degradation study of poly(lactic-L(+)-co-glycolic acid) in chloroform
title_full_unstemmed Degradation study of poly(lactic-L(+)-co-glycolic acid) in chloroform
title_sort degradation study of poly(lactic-l(+)-co-glycolic acid) in chloroform
description Polymer/solvent interaction has been of great interest in many fields, such as scaffold processing, polymer recycling and drug delivery system (DDS), among others. It has been reported that the effect of solvent on polymers could determine the final physical and chemical properties in specific applications. Thus, this article describes a degradation study of poly(lactic-L(+)-co-glycolic acid), or PLGA, in the presence of chloroform. The PLGA polymer was synthetized by ring opening polymerization (ROP). Five lactic/glycolic acid volumetric ratios (90/10, 80/20, 70/30, 60/40 and 50/50) were used to prepare PLGA. Copolymers were characterized using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) and static light scattering (SLS). Copolymer degradation was induced using chloroform as the solvent. FTIR was used to follow variations on the functional groups of copolymers during the PLGA degradation process. The study was conducted using the evidence provided from the modifications of OH wavelength bands (3000-3500 cm-1) obtained from FTIR. A viable reaction scheme to explain the degradation of the copolymer was developed based on the monomolecular constant reaction rates generated by the decomposition dynamic of OH groups.
publisher Universidad Autónoma Metropolitana, División de Ciencias Básicas e Ingeniería
publishDate 2015
url http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1665-27382015000300023
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AT vallejoi degradationstudyofpolylacticlcoglycolicacidinchloroform
AT coream degradationstudyofpolylacticlcoglycolicacidinchloroform
AT palacioseg degradationstudyofpolylacticlcoglycolicacidinchloroform
AT chairezi degradationstudyofpolylacticlcoglycolicacidinchloroform
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