Transient Elastography vs.Aspartate Aminotransferase to Platelet Ratio Index in Hepatitis C: A Meta-Analysis
ABSTRACT Background and rationale. Many different non-invasive methods have been studied with the purpose of staging liver fibrosis. The objective of this study was verifying if transient elastography is superior to aspartate aminotransferase to platelet ratio index for staging fibrosis in patients with chronic hepatitis C. Material and methods. A systematic review with meta-analysis of studies which evaluated both non-invasive tests and used biopsy as the reference standard was performed. A random-effects model was used, anticipating heterogeneity among studies. Diagnostic odds ratio was the main effect measure, and summary receiver operating characteristic curves were created. A sensitivity analysis was planned, in which the meta-analysis would be repeated excluding each study at a time. Results. Eight studies were included in the meta-analysis. Regarding the prediction of significant fibrosis, transient elastography and aspartate aminotransferase to platelet ratio index had diagnostic odds ratios of 11.70 (95% confidence interval = 7.13-19.21) and 8.56 (95% confidence interval = 4.90-14.94) respectively. Concerning the prediction of cirrhosis, transient elastography and aspartate aminotransferase to platelet ratio index had diagnostic odds ratios of 66.49 (95% confidence interval = 23.71- 186.48) and 7.47 (95% confidence interval = 4.88-11.43) respectively. Conclusion. In conclusion, there was no evidence of significant superiority of transient elastography over aspartate aminotransferase to platelet ratio index regarding the prediction of significant fibrosis, but the former proved to be better than the latter concerning prediction of cirrhosis.
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Asociación Mexicana de Hepatología A.C.
2017
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oai:scielo:S1665-268120170003003492017-10-03Transient Elastography vs.Aspartate Aminotransferase to Platelet Ratio Index in Hepatitis C: A Meta-AnalysisMattos,Ângelo Zambam deMattos,Angelo Alves de Viral hepatitis Fibrosis Non-invasive methods ABSTRACT Background and rationale. Many different non-invasive methods have been studied with the purpose of staging liver fibrosis. The objective of this study was verifying if transient elastography is superior to aspartate aminotransferase to platelet ratio index for staging fibrosis in patients with chronic hepatitis C. Material and methods. A systematic review with meta-analysis of studies which evaluated both non-invasive tests and used biopsy as the reference standard was performed. A random-effects model was used, anticipating heterogeneity among studies. Diagnostic odds ratio was the main effect measure, and summary receiver operating characteristic curves were created. A sensitivity analysis was planned, in which the meta-analysis would be repeated excluding each study at a time. Results. Eight studies were included in the meta-analysis. Regarding the prediction of significant fibrosis, transient elastography and aspartate aminotransferase to platelet ratio index had diagnostic odds ratios of 11.70 (95% confidence interval = 7.13-19.21) and 8.56 (95% confidence interval = 4.90-14.94) respectively. Concerning the prediction of cirrhosis, transient elastography and aspartate aminotransferase to platelet ratio index had diagnostic odds ratios of 66.49 (95% confidence interval = 23.71- 186.48) and 7.47 (95% confidence interval = 4.88-11.43) respectively. Conclusion. In conclusion, there was no evidence of significant superiority of transient elastography over aspartate aminotransferase to platelet ratio index regarding the prediction of significant fibrosis, but the former proved to be better than the latter concerning prediction of cirrhosis.info:eu-repo/semantics/openAccessAsociación Mexicana de Hepatología A.C.Annals of Hepatology v.16 n.3 20172017-06-01info:eu-repo/semantics/articletext/htmlhttp://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1665-26812017000300349en10.5604/16652681.1235477 |
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Mattos,Ângelo Zambam de Mattos,Angelo Alves de |
| spellingShingle |
Mattos,Ângelo Zambam de Mattos,Angelo Alves de Transient Elastography vs.Aspartate Aminotransferase to Platelet Ratio Index in Hepatitis C: A Meta-Analysis |
| author_facet |
Mattos,Ângelo Zambam de Mattos,Angelo Alves de |
| author_sort |
Mattos,Ângelo Zambam de |
| title |
Transient Elastography vs.Aspartate Aminotransferase to Platelet Ratio Index in Hepatitis C: A Meta-Analysis |
| title_short |
Transient Elastography vs.Aspartate Aminotransferase to Platelet Ratio Index in Hepatitis C: A Meta-Analysis |
| title_full |
Transient Elastography vs.Aspartate Aminotransferase to Platelet Ratio Index in Hepatitis C: A Meta-Analysis |
| title_fullStr |
Transient Elastography vs.Aspartate Aminotransferase to Platelet Ratio Index in Hepatitis C: A Meta-Analysis |
| title_full_unstemmed |
Transient Elastography vs.Aspartate Aminotransferase to Platelet Ratio Index in Hepatitis C: A Meta-Analysis |
| title_sort |
transient elastography vs.aspartate aminotransferase to platelet ratio index in hepatitis c: a meta-analysis |
| description |
ABSTRACT Background and rationale. Many different non-invasive methods have been studied with the purpose of staging liver fibrosis. The objective of this study was verifying if transient elastography is superior to aspartate aminotransferase to platelet ratio index for staging fibrosis in patients with chronic hepatitis C. Material and methods. A systematic review with meta-analysis of studies which evaluated both non-invasive tests and used biopsy as the reference standard was performed. A random-effects model was used, anticipating heterogeneity among studies. Diagnostic odds ratio was the main effect measure, and summary receiver operating characteristic curves were created. A sensitivity analysis was planned, in which the meta-analysis would be repeated excluding each study at a time. Results. Eight studies were included in the meta-analysis. Regarding the prediction of significant fibrosis, transient elastography and aspartate aminotransferase to platelet ratio index had diagnostic odds ratios of 11.70 (95% confidence interval = 7.13-19.21) and 8.56 (95% confidence interval = 4.90-14.94) respectively. Concerning the prediction of cirrhosis, transient elastography and aspartate aminotransferase to platelet ratio index had diagnostic odds ratios of 66.49 (95% confidence interval = 23.71- 186.48) and 7.47 (95% confidence interval = 4.88-11.43) respectively. Conclusion. In conclusion, there was no evidence of significant superiority of transient elastography over aspartate aminotransferase to platelet ratio index regarding the prediction of significant fibrosis, but the former proved to be better than the latter concerning prediction of cirrhosis. |
| publisher |
Asociación Mexicana de Hepatología A.C. |
| publishDate |
2017 |
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http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1665-26812017000300349 |
| work_keys_str_mv |
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