Multisystem inflammatory syndrome and COVID-19: a scoping review

Abstract Background: Multisystem inflammatory syndrome temporally associated with COVID-19 presents with similar symptomatology and therapeutic approach to Kawasaki disease in the pediatric population. Given the novelty of the disease and the growing scientific literature on the subject, it is relevant to collect and report available scientific information. This review aimed to explore the medical evidence on multisystem inflammatory syndrome temporally associated with COVID-19 in a population under 18 years of age. Methods: We conducted a scoping review using Scopus and PubMed, including observational (cohort, case-control, and cross-sectional) studies and case series Results: Of the total articles reviewed as of April 10, 2021, 45 articles met eligibility criteria: case series (n = 32), retrospective cohort studies (n = 6), prospective cohort studies (n = 4), case-control studies (n = 2), and cross-sectional studies (n = 1). Gastrointestinal and respiratory symptoms and myocardial dysfunction are the most commonly reported. The most relevant paraclinical markers were lymphopenia, thrombocytopenia, and elevated D-dimer levels Conclusions: The multisystem inflammatory syndrome temporally associated with COVID-19 presents a broad spectrum of signs and symptoms. Aneurysms of the coronary arteries and myocarditis are usually present in the acute phases of the disease. The early diagnosis led by a multidisciplinary group of pediatric intensivists, infectious disease specialists, cardiologists, and rheumatologists allows adequate and effective medical management.

Bibliographic Details

Main Authors:	Tuta-Quintero,Eduardo, Martínez-Ayala,Camila, Mantilla-Beltrán,Gabriela, Rueda-Rodríguez,Alejandro, Pimentel,Juan
Format:	Digital revista
Language:	English
Published:	Instituto Nacional de Salud, Hospital Infantil de México Federico Gómez 2022
Online Access:	http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1665-11462022000200069
Tags:	Add Tag No Tags, Be the first to tag this record!