Fatal case of donor-derived colistin-resistant carbapenemase-producing Klebsiella pneumoniae transmission in cardiac transplantation

ABSTRACT Herein we report a fatal case of donor-derived transmission of XDR-resistant carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) in cardiac transplantation. A 59-year-old male patient with non-obstructive hypertrophic cardiomyopathy underwent heart transplantation. On day 5 post-operation, blood cultures from the donor were positive for colistin-resistant carbapenemase-producing K. pneumoniae (ColR KPC-Kp) susceptible only to amikacin. Recipient blood cultures were also positive for ColR KPC-Kp with the same sensitivity profile as the donor isolate with an identical PFGE pattern. The patient was treated with double-carbapenems and amikacin. The patient evolved to pericarditis, osteomyelitis, and pulmonary necrosis, all fragment cultures positive for the same agent. The patient developed septic shock, multiple organ failure and died on day 50 post-transplantation. Based on current microbiological scenario worldwide the possibility of transmitting multidrug resistant (MDR) organisms should be considered.

Bibliographic Details

Main Authors:	Galvão,Lisia Miglioli, Oliveira,Anna Paula Romero de, Ibanês,Aline Santos, Monteiro,Jussimara, Inoue,Fernanda, Dantas,Daniel Chagas, Sanchez,Flavio, Santos,Daniel Wagner, Abboud,Cely Saad
Format:	Digital revista
Language:	English
Published:	Brazilian Society of Infectious Diseases 2018
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000300235
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